Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models

BACKGROUND: Cerebral amyloidosis, neuroinflammation, and tauopathy are key features of Alzheimer’s disease (AD), but interactions among these features remain poorly understood. Our previous multiscale molecular network models of AD revealed TYROBP as a key driver of an immune- and microglia-specific...

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Detalles Bibliográficos
Autores principales: Sekiya, Michiko, Wang, Minghui, Fujisaki, Naoki, Sakakibara, Yasufumi, Quan, Xiuming, Ehrlich, Michelle E., De Jager, Philip L., Bennett, David A., Schadt, Eric E., Gandy, Sam, Ando, Kanae, Zhang, Bin, Iijima, Koichi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875009/
https://www.ncbi.nlm.nih.gov/pubmed/29598827
http://dx.doi.org/10.1186/s13073-018-0530-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875009/
https://www.ncbi.nlm.nih.gov/pubmed/29598827
http://dx.doi.org/10.1186/s13073-018-0530-9

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