Cargando…

Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models

BACKGROUND: Cerebral amyloidosis, neuroinflammation, and tauopathy are key features of Alzheimer’s disease (AD), but interactions among these features remain poorly understood. Our previous multiscale molecular network models of AD revealed TYROBP as a key driver of an immune- and microglia-specific...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sekiya, Michiko, Wang, Minghui, Fujisaki, Naoki, Sakakibara, Yasufumi, Quan, Xiuming, Ehrlich, Michelle E., De Jager, Philip L., Bennett, David A., Schadt, Eric E., Gandy, Sam, Ando, Kanae, Zhang, Bin, Iijima, Koichi M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875009/ https://www.ncbi.nlm.nih.gov/pubmed/29598827 http://dx.doi.org/10.1186/s13073-018-0530-9

Ejemplares similares

Reactive or transgenic increase in microglial TYROBP reveals a TREM2‐independent TYROBP–APOE link in wild‐type and Alzheimer's‐related mice
por: Audrain, Mickael, et al.
Publicado: (2020)

Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2
por: Haure-Mirande, Jean-Vianney, et al.
Publicado: (2022)

Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila
por: Sakakibara, Yasufumi, et al.
Publicado: (2018)

Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology
por: Haure-Mirande, Jean-Vianney, et al.
Publicado: (2017)

Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity
por: Ando, Kanae, et al.
Publicado: (2016)

Distinct brain pathologies associated with Alzheimer’s disease biomarker-related phospho-tau 181 and phospho-tau 217 in App knock-in mouse models of amyloid-β amyloidosis
por: Hirota, Yu, et al.
Publicado: (2022)

Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1
por: Iijima-Ando, Kanae, et al.
Publicado: (2012)

Alzheimer’s Disease-Related Phospho-Tau181 Signals Are Localized to Demyelinated Axons of Parvalbumin-Positive GABAergic Interneurons in an App Knock-In Mouse Model of Amyloid-β Pathology
por: Hirota, Yu, et al.
Publicado: (2023)

Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau
por: Audrain, Mickael, et al.
Publicado: (2018)

Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration
por: Sakakibara, Yasufumi, et al.
Publicado: (2023)

Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden
por: Haure-Mirande, Jean-Vianney, et al.
Publicado: (2018)

Correction: Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden
por: Haure-Mirande, Jean-Vianney, et al.
Publicado: (2018)

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis
por: Sakakibara, Yasufumi, et al.
Publicado: (2018)

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease
por: Sakakibara, Yasufumi, et al.
Publicado: (2019)

CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau
por: Henjum, Kristi, et al.
Publicado: (2018)

Mitochondrial Mislocalization Underlies Aβ42-Induced Neuronal Dysfunction in a Drosophila Model of Alzheimer's Disease
por: Iijima-Ando, Kanae, et al.
Publicado: (2009)

miR155, TREM2, INPP5D: Disease stage and cell type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy
por: Gandy, Sam, et al.
Publicado: (2023)

Correction: miR155, TREM2, INPP5D: Disease stage and cell-type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy
por: Gandy, Sam, et al.
Publicado: (2023)

CXCR4 and TYROBP mediate the development of atrial fibrillation via inflammation
por: Zhang, Yan‐Fei, et al.
Publicado: (2022)

Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis
por: Sakakibara, Yasufumi, et al.
Publicado: (2021)

Aβ42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila
por: Iijima, Koichi, et al.
Publicado: (2008)

Phenotypic analysis of a transgenic Drosophila model of Alzheimer’s amyloid-β toxicity
por: Sekiya, Michiko, et al.
Publicado: (2021)

TYROBP is a potential prognostic biomarker of clear cell renal cell carcinoma
por: Wu, Ping, et al.
Publicado: (2020)

TREM2 function impedes tau seeding in neuritic plaques
por: Leyns, Cheryl E.G., et al.
Publicado: (2019)

TYROBP, TLR4 and ITGAM regulated macrophages polarization and immune checkpoints expression in osteosarcoma
por: Liang, Tuo, et al.
Publicado: (2021)

TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo
por: Lee-Gosselin, Audrey, et al.
Publicado: (2023)

The role of TREM2 in Alzheimer’s disease: from the perspective of Tau
por: Huang, Wendi, et al.
Publicado: (2023)

Downregulation of m6A Methyltransferase in the Hippocampus of Tyrobp(–/–) Mice and Implications for Learning and Memory Deficits
por: Lv, Zhanyun, et al.
Publicado: (2022)

Physiological Mouse Brain Aβ Levels Are Not Related to the Phosphorylation State of Threonine-668 of Alzheimer's APP
por: Sano, Yoshitake, et al.
Publicado: (2006)

Friend turned foe: TREM2 agonist in battles against tau
por: Carling, Gillian, et al.
Publicado: (2022)

TREM2 and microglia exosomes: a potential highway for pathological tau
por: Jain, Nimansha, et al.
Publicado: (2022)

Dissecting the daily feeding pattern: Peripheral CLOCK/CYCLE generate the feeding/fasting episodes and neuronal molecular clocks synchronize them
por: Maruko, Akiko, et al.
Publicado: (2023)

Regulation of Energy Stores and Feeding by Neuronal and Peripheral CREB Activity in Drosophila
por: Iijima, Koichi, et al.
Publicado: (2009)

Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
por: Zhu, Bing, et al.
Publicado: (2022)

TREM2 Agonism with a Monoclonal Antibody Attenuates Tau Pathology and Neurodegeneration
por: Fassler, Michael, et al.
Publicado: (2023)

The Fgl2 interaction with Tyrobp promotes the proliferation of cutaneous squamous cell carcinoma by regulating ERK-dependent autophagy
por: Zeng, Mei, et al.
Publicado: (2022)

Elevated TYROBP expression predicts poor prognosis and high tumor immune infiltration in patients with low-grade glioma
por: Lu, Jiajie, et al.
Publicado: (2021)

Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces β-Amyloid Load in Males and Females
por: Pan, Allen L., et al.
Publicado: (2022)

Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading
por: Jain, Nimansha, et al.
Publicado: (2022)

Identification of TYROBP and C1QB as Two Novel Key Genes With Prognostic Value in Gastric Cancer by Network Analysis
por: Jiang, Junjie, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_rru4lo6ra99sd87rcga6uneblb