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Hydrogen peroxide-triggered gene silencing in mammalian cells through boronated antisense oligonucleotides
Hydrogen peroxide (H(2)O(2)) is a reactive oxygen species (ROS) involved in various diseases, including neurodegeneration, diabetes, and cancer. Here, we introduce a new approach to use H(2)O(2) to modulate specific gene expression in mammalian cells. H(2)O(2)-responsive nucleoside analogues, in whi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875086/ https://www.ncbi.nlm.nih.gov/pubmed/29629168 http://dx.doi.org/10.1039/c7sc04318j |