Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017

Avian influenza A(H7N9) virus has caused 5 epidemic waves in China since its emergence in 2013. We investigated the dynamic changes of antibody response to this virus over 1 year postinfection in 25 patients in Suzhou City, Jiangsu Province, China, who had laboratory-confirmed infections during the...

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Detalles Bibliográficos
Autores principales: Ma, Mai-Juan, Liu, Cheng, Wu, Meng-Na, Zhao, Teng, Wang, Guo-Lin, Yang, Yang, Gu, Hong-Jing, Cui, Peng-Wei, Pang, Yuan-Yuan, Tan, Ya-Yun, Hang, Hui, Lin, Bao, Qin, Jiang-Chun, Fang, Li-Qun, Cao, Wu-Chun, Cheng, Li-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875250/
https://www.ncbi.nlm.nih.gov/pubmed/29432091
http://dx.doi.org/10.3201/eid2404.171995
Descripción
Sumario:Avian influenza A(H7N9) virus has caused 5 epidemic waves in China since its emergence in 2013. We investigated the dynamic changes of antibody response to this virus over 1 year postinfection in 25 patients in Suzhou City, Jiangsu Province, China, who had laboratory-confirmed infections during the fifth epidemic wave, October 1, 2016–February 14, 2017. Most survivors had relatively robust antibody responses that decreased but remained detectable at 1 year. Antibody response was variable; several survivors had low or undetectable antibody titers. Hemagglutination inhibition titer was >1:40 for <40% of the survivors. Measured in vitro in infected mice, hemagglutination inhibition titer predicted serum protective ability. Our findings provide a helpful serologic guideline for identifying subclinical infections and for developing effective vaccines and therapeutics to counter H7N9 virus infections.

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