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Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017
Avian influenza A(H7N9) virus has caused 5 epidemic waves in China since its emergence in 2013. We investigated the dynamic changes of antibody response to this virus over 1 year postinfection in 25 patients in Suzhou City, Jiangsu Province, China, who had laboratory-confirmed infections during the...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875250/ https://www.ncbi.nlm.nih.gov/pubmed/29432091 http://dx.doi.org/10.3201/eid2404.171995 |
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author | Ma, Mai-Juan Liu, Cheng Wu, Meng-Na Zhao, Teng Wang, Guo-Lin Yang, Yang Gu, Hong-Jing Cui, Peng-Wei Pang, Yuan-Yuan Tan, Ya-Yun Hang, Hui Lin, Bao Qin, Jiang-Chun Fang, Li-Qun Cao, Wu-Chun Cheng, Li-Ling |
author_facet | Ma, Mai-Juan Liu, Cheng Wu, Meng-Na Zhao, Teng Wang, Guo-Lin Yang, Yang Gu, Hong-Jing Cui, Peng-Wei Pang, Yuan-Yuan Tan, Ya-Yun Hang, Hui Lin, Bao Qin, Jiang-Chun Fang, Li-Qun Cao, Wu-Chun Cheng, Li-Ling |
author_sort | Ma, Mai-Juan |
collection | PubMed |
description | Avian influenza A(H7N9) virus has caused 5 epidemic waves in China since its emergence in 2013. We investigated the dynamic changes of antibody response to this virus over 1 year postinfection in 25 patients in Suzhou City, Jiangsu Province, China, who had laboratory-confirmed infections during the fifth epidemic wave, October 1, 2016–February 14, 2017. Most survivors had relatively robust antibody responses that decreased but remained detectable at 1 year. Antibody response was variable; several survivors had low or undetectable antibody titers. Hemagglutination inhibition titer was >1:40 for <40% of the survivors. Measured in vitro in infected mice, hemagglutination inhibition titer predicted serum protective ability. Our findings provide a helpful serologic guideline for identifying subclinical infections and for developing effective vaccines and therapeutics to counter H7N9 virus infections. |
format | Online Article Text |
id | pubmed-5875250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-58752502018-04-06 Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017 Ma, Mai-Juan Liu, Cheng Wu, Meng-Na Zhao, Teng Wang, Guo-Lin Yang, Yang Gu, Hong-Jing Cui, Peng-Wei Pang, Yuan-Yuan Tan, Ya-Yun Hang, Hui Lin, Bao Qin, Jiang-Chun Fang, Li-Qun Cao, Wu-Chun Cheng, Li-Ling Emerg Infect Dis Research Avian influenza A(H7N9) virus has caused 5 epidemic waves in China since its emergence in 2013. We investigated the dynamic changes of antibody response to this virus over 1 year postinfection in 25 patients in Suzhou City, Jiangsu Province, China, who had laboratory-confirmed infections during the fifth epidemic wave, October 1, 2016–February 14, 2017. Most survivors had relatively robust antibody responses that decreased but remained detectable at 1 year. Antibody response was variable; several survivors had low or undetectable antibody titers. Hemagglutination inhibition titer was >1:40 for <40% of the survivors. Measured in vitro in infected mice, hemagglutination inhibition titer predicted serum protective ability. Our findings provide a helpful serologic guideline for identifying subclinical infections and for developing effective vaccines and therapeutics to counter H7N9 virus infections. Centers for Disease Control and Prevention 2018-04 /pmc/articles/PMC5875250/ /pubmed/29432091 http://dx.doi.org/10.3201/eid2404.171995 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Ma, Mai-Juan Liu, Cheng Wu, Meng-Na Zhao, Teng Wang, Guo-Lin Yang, Yang Gu, Hong-Jing Cui, Peng-Wei Pang, Yuan-Yuan Tan, Ya-Yun Hang, Hui Lin, Bao Qin, Jiang-Chun Fang, Li-Qun Cao, Wu-Chun Cheng, Li-Ling Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017 |
title | Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017 |
title_full | Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017 |
title_fullStr | Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017 |
title_full_unstemmed | Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017 |
title_short | Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017 |
title_sort | influenza a(h7n9) virus antibody responses in survivors 1 year after infection, china, 2017 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875250/ https://www.ncbi.nlm.nih.gov/pubmed/29432091 http://dx.doi.org/10.3201/eid2404.171995 |
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