Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal

We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase acti...

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Autores principales: Isidro, Joana, Santos, Andrea, Nunes, Alexandra, Borges, Vítor, Silva, Catarina, Vieira, Luís, Mendes, Aristides L., Serrano, Mónica, Henriques, Adriano O., Gomes, João Paulo, Oleastro, Mónica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875251/
https://www.ncbi.nlm.nih.gov/pubmed/29553322
http://dx.doi.org/10.3201/eid2404.170095
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author Isidro, Joana
Santos, Andrea
Nunes, Alexandra
Borges, Vítor
Silva, Catarina
Vieira, Luís
Mendes, Aristides L.
Serrano, Mónica
Henriques, Adriano O.
Gomes, João Paulo
Oleastro, Mónica
author_facet Isidro, Joana
Santos, Andrea
Nunes, Alexandra
Borges, Vítor
Silva, Catarina
Vieira, Luís
Mendes, Aristides L.
Serrano, Mónica
Henriques, Adriano O.
Gomes, João Paulo
Oleastro, Mónica
author_sort Isidro, Joana
collection PubMed
description We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.
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spelling pubmed-58752512018-04-06 Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal Isidro, Joana Santos, Andrea Nunes, Alexandra Borges, Vítor Silva, Catarina Vieira, Luís Mendes, Aristides L. Serrano, Mónica Henriques, Adriano O. Gomes, João Paulo Oleastro, Mónica Emerg Infect Dis Dispatch We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance. Centers for Disease Control and Prevention 2018-04 /pmc/articles/PMC5875251/ /pubmed/29553322 http://dx.doi.org/10.3201/eid2404.170095 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Isidro, Joana
Santos, Andrea
Nunes, Alexandra
Borges, Vítor
Silva, Catarina
Vieira, Luís
Mendes, Aristides L.
Serrano, Mónica
Henriques, Adriano O.
Gomes, João Paulo
Oleastro, Mónica
Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
title Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
title_full Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
title_fullStr Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
title_full_unstemmed Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
title_short Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal
title_sort imipenem resistance in clostridium difficile ribotype 017, portugal
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875251/
https://www.ncbi.nlm.nih.gov/pubmed/29553322
http://dx.doi.org/10.3201/eid2404.170095
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