Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans

To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2–482R, polymerase basic 2–588V, and polymerase acidic–497R individually or additively enhanced virus polymerase activity, ind...

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Detalles Bibliográficos
Autores principales: Yamayoshi, Seiya, Kiso, Maki, Yasuhara, Atsuhiro, Ito, Mutsumi, Shu, Yuelong, Kawaoka, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875272/
https://www.ncbi.nlm.nih.gov/pubmed/29553313
http://dx.doi.org/10.3201/eid2404.171509
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author Yamayoshi, Seiya
Kiso, Maki
Yasuhara, Atsuhiro
Ito, Mutsumi
Shu, Yuelong
Kawaoka, Yoshihiro
author_facet Yamayoshi, Seiya
Kiso, Maki
Yasuhara, Atsuhiro
Ito, Mutsumi
Shu, Yuelong
Kawaoka, Yoshihiro
author_sort Yamayoshi, Seiya
collection PubMed
description To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2–482R, polymerase basic 2–588V, and polymerase acidic–497R individually or additively enhanced virus polymerase activity, indicating that multiple replication-enhancing mutations in 1 isolate may contribute to virulence.
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spelling pubmed-58752722018-04-06 Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans Yamayoshi, Seiya Kiso, Maki Yasuhara, Atsuhiro Ito, Mutsumi Shu, Yuelong Kawaoka, Yoshihiro Emerg Infect Dis Dispatch To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2–482R, polymerase basic 2–588V, and polymerase acidic–497R individually or additively enhanced virus polymerase activity, indicating that multiple replication-enhancing mutations in 1 isolate may contribute to virulence. Centers for Disease Control and Prevention 2018-04 /pmc/articles/PMC5875272/ /pubmed/29553313 http://dx.doi.org/10.3201/eid2404.171509 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Yamayoshi, Seiya
Kiso, Maki
Yasuhara, Atsuhiro
Ito, Mutsumi
Shu, Yuelong
Kawaoka, Yoshihiro
Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans
title Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans
title_full Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans
title_fullStr Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans
title_full_unstemmed Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans
title_short Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans
title_sort enhanced replication of highly pathogenic influenza a(h7n9) virus in humans
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875272/
https://www.ncbi.nlm.nih.gov/pubmed/29553313
http://dx.doi.org/10.3201/eid2404.171509
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