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Comparison of high‐dose‐rate intracavitary brachytherapy dosimetry with and without anesthesia in patients with cervical carcinoma

This study compares the dosimetry of high‐dose‐rate intracavitary brachytherapy (HDR‐ICBT) performed with and without general anesthesia/spinal anesthesia (GA/SA) in patients with cervical carcinoma. We retrospectively retrieved the records of 138 HDR‐ICBT applicator insertions performed in 46 patie...

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Autores principales: Sharma, Daya N., Chaudhari, Pritee, Sharma, Seema, Gupta, Leena, Jagadesan, Pandjatcharam, Rath, Goura K., Julka, Pramod K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875476/
https://www.ncbi.nlm.nih.gov/pubmed/24710456
http://dx.doi.org/10.1120/jacmp.v15i2.4670
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author Sharma, Daya N.
Chaudhari, Pritee
Sharma, Seema
Gupta, Leena
Jagadesan, Pandjatcharam
Rath, Goura K.
Julka, Pramod K.
author_facet Sharma, Daya N.
Chaudhari, Pritee
Sharma, Seema
Gupta, Leena
Jagadesan, Pandjatcharam
Rath, Goura K.
Julka, Pramod K.
author_sort Sharma, Daya N.
collection PubMed
description This study compares the dosimetry of high‐dose‐rate intracavitary brachytherapy (HDR‐ICBT) performed with and without general anesthesia/spinal anesthesia (GA/SA) in patients with cervical carcinoma. We retrospectively retrieved the records of 138 HDR‐ICBT applicator insertions performed in 46 patients: 69 performed with GA/SA (anesthesia group known as AG) in 23 patients, and 69 performed without GA/SA (nonanesthesia group known as NAG) in 23 patients. The intracavitary brachytherapy (ICBT) application was done with central tandem and two vaginal ovoids. For each ICBT plan, a high‐dose‐rate (HDR) dose of 7 Gy was prescribed to point A. From each plan, the doses to Point B right [Formula: see text] , Point B left [Formula: see text] , bladder and rectal reference points ([Formula: see text] and [Formula: see text]) were recorded and compared in the two groups. Student's t‐test was applied to find out the significance of difference. The two groups were comparable in terms of demography and clinical characteristics. Mean Point [Formula: see text] doses in AG and NAG were 1.89 Gy (27% of Point A dose) and 1.82 Gy (26% of Point A dose), respectively. Mean Point [Formula: see text] doses in AG and NAG were 1.91 Gy (27% of Point A dose) and 1.85 Gy (26% of point A), respectively (p‐value 0.7). The mean dose to [Formula: see text] in AG and NAG was 5.03 Gy and 4.90 Gy, respectively (p‐value 0.6). The mean dose to [Formula: see text] was significantly higher in AG than NAG (5.09 Gy vs. 4.49 Gy, p‐value 0.01). Although based on conventional 2D dosimetry planning, our study has demonstrated that avoiding GA/SA does not result in inferior HDR‐ICBT dosimetry. PACS number: 87.53.Jw, 87.50.cm
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spelling pubmed-58754762018-04-02 Comparison of high‐dose‐rate intracavitary brachytherapy dosimetry with and without anesthesia in patients with cervical carcinoma Sharma, Daya N. Chaudhari, Pritee Sharma, Seema Gupta, Leena Jagadesan, Pandjatcharam Rath, Goura K. Julka, Pramod K. J Appl Clin Med Phys Radiation Oncology Physics This study compares the dosimetry of high‐dose‐rate intracavitary brachytherapy (HDR‐ICBT) performed with and without general anesthesia/spinal anesthesia (GA/SA) in patients with cervical carcinoma. We retrospectively retrieved the records of 138 HDR‐ICBT applicator insertions performed in 46 patients: 69 performed with GA/SA (anesthesia group known as AG) in 23 patients, and 69 performed without GA/SA (nonanesthesia group known as NAG) in 23 patients. The intracavitary brachytherapy (ICBT) application was done with central tandem and two vaginal ovoids. For each ICBT plan, a high‐dose‐rate (HDR) dose of 7 Gy was prescribed to point A. From each plan, the doses to Point B right [Formula: see text] , Point B left [Formula: see text] , bladder and rectal reference points ([Formula: see text] and [Formula: see text]) were recorded and compared in the two groups. Student's t‐test was applied to find out the significance of difference. The two groups were comparable in terms of demography and clinical characteristics. Mean Point [Formula: see text] doses in AG and NAG were 1.89 Gy (27% of Point A dose) and 1.82 Gy (26% of Point A dose), respectively. Mean Point [Formula: see text] doses in AG and NAG were 1.91 Gy (27% of Point A dose) and 1.85 Gy (26% of point A), respectively (p‐value 0.7). The mean dose to [Formula: see text] in AG and NAG was 5.03 Gy and 4.90 Gy, respectively (p‐value 0.6). The mean dose to [Formula: see text] was significantly higher in AG than NAG (5.09 Gy vs. 4.49 Gy, p‐value 0.01). Although based on conventional 2D dosimetry planning, our study has demonstrated that avoiding GA/SA does not result in inferior HDR‐ICBT dosimetry. PACS number: 87.53.Jw, 87.50.cm John Wiley and Sons Inc. 2014-03-06 /pmc/articles/PMC5875476/ /pubmed/24710456 http://dx.doi.org/10.1120/jacmp.v15i2.4670 Text en © 2014 The Authors. This is an open access article under the terms of the http://creativecommons.org/licenses/by/3.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Sharma, Daya N.
Chaudhari, Pritee
Sharma, Seema
Gupta, Leena
Jagadesan, Pandjatcharam
Rath, Goura K.
Julka, Pramod K.
Comparison of high‐dose‐rate intracavitary brachytherapy dosimetry with and without anesthesia in patients with cervical carcinoma
title Comparison of high‐dose‐rate intracavitary brachytherapy dosimetry with and without anesthesia in patients with cervical carcinoma
title_full Comparison of high‐dose‐rate intracavitary brachytherapy dosimetry with and without anesthesia in patients with cervical carcinoma
title_fullStr Comparison of high‐dose‐rate intracavitary brachytherapy dosimetry with and without anesthesia in patients with cervical carcinoma
title_full_unstemmed Comparison of high‐dose‐rate intracavitary brachytherapy dosimetry with and without anesthesia in patients with cervical carcinoma
title_short Comparison of high‐dose‐rate intracavitary brachytherapy dosimetry with and without anesthesia in patients with cervical carcinoma
title_sort comparison of high‐dose‐rate intracavitary brachytherapy dosimetry with and without anesthesia in patients with cervical carcinoma
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875476/
https://www.ncbi.nlm.nih.gov/pubmed/24710456
http://dx.doi.org/10.1120/jacmp.v15i2.4670
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