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Impaired autonomic function in adolescents born preterm

Preterm birth temporarily disrupts autonomic nervous system (ANS) development, and the long‐term impacts of disrupted fetal development are unclear in children. Abnormal cardiac ANS function is associated with worse health outcomes, and has been identified as a risk factor for cardiovascular disease...

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Autores principales: Haraldsdottir, Kristin, Watson, Andrew M., Goss, Kara N., Beshish, Arij G., Pegelow, David F., Palta, Mari, Tetri, Laura H., Barton, Gregory P., Brix, Melissa D., Centanni, Ryan M., Eldridge, Marlowe W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875539/
https://www.ncbi.nlm.nih.gov/pubmed/29595875
http://dx.doi.org/10.14814/phy2.13620
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author Haraldsdottir, Kristin
Watson, Andrew M.
Goss, Kara N.
Beshish, Arij G.
Pegelow, David F.
Palta, Mari
Tetri, Laura H.
Barton, Gregory P.
Brix, Melissa D.
Centanni, Ryan M.
Eldridge, Marlowe W.
author_facet Haraldsdottir, Kristin
Watson, Andrew M.
Goss, Kara N.
Beshish, Arij G.
Pegelow, David F.
Palta, Mari
Tetri, Laura H.
Barton, Gregory P.
Brix, Melissa D.
Centanni, Ryan M.
Eldridge, Marlowe W.
author_sort Haraldsdottir, Kristin
collection PubMed
description Preterm birth temporarily disrupts autonomic nervous system (ANS) development, and the long‐term impacts of disrupted fetal development are unclear in children. Abnormal cardiac ANS function is associated with worse health outcomes, and has been identified as a risk factor for cardiovascular disease. We used heart rate variability (HRV) in the time domain (standard deviation of RR intervals, SDRR; and root means squared of successive differences, RMSSD) and frequency domain (high frequency, HF; and low frequency, LF) at rest, as well as heart rate recovery (HRR) following maximal exercise, to assess autonomic function in adolescent children born preterm. Adolescents born preterm (less than 36 weeks gestation at birth) in 2003 and 2004 and healthy age‐matched full‐term controls participated. Wilcoxon Rank Sum tests were used to compare variables between control and preterm groups. Twenty‐one adolescents born preterm and 20 term‐born controls enrolled in the study. Preterm‐born subjects had lower time‐domain HRV, including SDRR (69.1 ± 33.8 vs. 110.1 ± 33.0 msec, respectively, P = 0.008) and RMSSD (58.8 ± 38.2 vs. 101.5 ± 36.2 msec, respectively, P = 0.012), with higher LF variability in preterm subjects. HRR after maximal exercise was slower in preterm‐born subjects at 1 min (30 ± 12 vs. 39 ± 9 bpm, respectively, P = 0.013) and 2 min (52 ± 10 vs. 60 ± 10 bpm, respectively, P = 0.016). This study is the first report of autonomic dysfunction in adolescents born premature. Given prior association of impaired HRV with adult cardiovascular disease, additional investigations into the mechanisms of autonomic dysfunction in this population are warranted.
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spelling pubmed-58755392018-04-02 Impaired autonomic function in adolescents born preterm Haraldsdottir, Kristin Watson, Andrew M. Goss, Kara N. Beshish, Arij G. Pegelow, David F. Palta, Mari Tetri, Laura H. Barton, Gregory P. Brix, Melissa D. Centanni, Ryan M. Eldridge, Marlowe W. Physiol Rep Original Research Preterm birth temporarily disrupts autonomic nervous system (ANS) development, and the long‐term impacts of disrupted fetal development are unclear in children. Abnormal cardiac ANS function is associated with worse health outcomes, and has been identified as a risk factor for cardiovascular disease. We used heart rate variability (HRV) in the time domain (standard deviation of RR intervals, SDRR; and root means squared of successive differences, RMSSD) and frequency domain (high frequency, HF; and low frequency, LF) at rest, as well as heart rate recovery (HRR) following maximal exercise, to assess autonomic function in adolescent children born preterm. Adolescents born preterm (less than 36 weeks gestation at birth) in 2003 and 2004 and healthy age‐matched full‐term controls participated. Wilcoxon Rank Sum tests were used to compare variables between control and preterm groups. Twenty‐one adolescents born preterm and 20 term‐born controls enrolled in the study. Preterm‐born subjects had lower time‐domain HRV, including SDRR (69.1 ± 33.8 vs. 110.1 ± 33.0 msec, respectively, P = 0.008) and RMSSD (58.8 ± 38.2 vs. 101.5 ± 36.2 msec, respectively, P = 0.012), with higher LF variability in preterm subjects. HRR after maximal exercise was slower in preterm‐born subjects at 1 min (30 ± 12 vs. 39 ± 9 bpm, respectively, P = 0.013) and 2 min (52 ± 10 vs. 60 ± 10 bpm, respectively, P = 0.016). This study is the first report of autonomic dysfunction in adolescents born premature. Given prior association of impaired HRV with adult cardiovascular disease, additional investigations into the mechanisms of autonomic dysfunction in this population are warranted. John Wiley and Sons Inc. 2018-03-29 /pmc/articles/PMC5875539/ /pubmed/29595875 http://dx.doi.org/10.14814/phy2.13620 Text en © 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Haraldsdottir, Kristin
Watson, Andrew M.
Goss, Kara N.
Beshish, Arij G.
Pegelow, David F.
Palta, Mari
Tetri, Laura H.
Barton, Gregory P.
Brix, Melissa D.
Centanni, Ryan M.
Eldridge, Marlowe W.
Impaired autonomic function in adolescents born preterm
title Impaired autonomic function in adolescents born preterm
title_full Impaired autonomic function in adolescents born preterm
title_fullStr Impaired autonomic function in adolescents born preterm
title_full_unstemmed Impaired autonomic function in adolescents born preterm
title_short Impaired autonomic function in adolescents born preterm
title_sort impaired autonomic function in adolescents born preterm
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875539/
https://www.ncbi.nlm.nih.gov/pubmed/29595875
http://dx.doi.org/10.14814/phy2.13620
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