Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems

Modeling human disease in animals is an important strategy to discover potential methods of intervention. We suggest that there is much to be gained by employing a multi-model approach that takes advantage of different animal systems used in the laboratory simultaneously. We use the example of model...

Descripción completa

Detalles Bibliográficos
Autores principales: Lim, Chu Hsien, Mathuru, Ajay S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875559/
https://www.ncbi.nlm.nih.gov/pubmed/29615550
http://dx.doi.org/10.3390/jdb6010001
_version_ 1783310369661386752
author Lim, Chu Hsien
Mathuru, Ajay S.
author_facet Lim, Chu Hsien
Mathuru, Ajay S.
author_sort Lim, Chu Hsien
collection PubMed
description Modeling human disease in animals is an important strategy to discover potential methods of intervention. We suggest that there is much to be gained by employing a multi-model approach that takes advantage of different animal systems used in the laboratory simultaneously. We use the example of modeling Alzheimer’s disease in Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio to illustrate how such an approach can be employed to investigate the pathophysiology of the disease.
format Online
Article
Text
id pubmed-5875559
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-58755592018-03-30 Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems Lim, Chu Hsien Mathuru, Ajay S. J Dev Biol Commentary Modeling human disease in animals is an important strategy to discover potential methods of intervention. We suggest that there is much to be gained by employing a multi-model approach that takes advantage of different animal systems used in the laboratory simultaneously. We use the example of modeling Alzheimer’s disease in Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio to illustrate how such an approach can be employed to investigate the pathophysiology of the disease. MDPI 2017-12-22 /pmc/articles/PMC5875559/ /pubmed/29615550 http://dx.doi.org/10.3390/jdb6010001 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Lim, Chu Hsien
Mathuru, Ajay S.
Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems
title Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems
title_full Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems
title_fullStr Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems
title_full_unstemmed Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems
title_short Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems
title_sort modeling alzheimer’s and other age related human diseases in embryonic systems
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875559/
https://www.ncbi.nlm.nih.gov/pubmed/29615550
http://dx.doi.org/10.3390/jdb6010001
work_keys_str_mv AT limchuhsien modelingalzheimersandotheragerelatedhumandiseasesinembryonicsystems
AT mathuruajays modelingalzheimersandotheragerelatedhumandiseasesinembryonicsystems

Ejemplares similares