Estrogen Deficiency Promotes Hepatic Steatosis via a Glucocorticoid Receptor-Dependent Mechanism in Mice

Glucocorticoids (GCs) are master regulators of systemic metabolism. Intriguingly, Cushing’s syndrome, a disorder of excessive GCs, phenocopies several menopause-induced metabolic pathologies. Here, we show that the glucocorticoid receptor (GR) drives steatosis in hypogonadal female mice because hepa...

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Detalles Bibliográficos
Autores principales: Quinn, Matthew A., Xu, Xiaojiang, Ronfani, Melania, Cidlowski, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875726/
https://www.ncbi.nlm.nih.gov/pubmed/29514097
http://dx.doi.org/10.1016/j.celrep.2018.02.041

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