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Incidence and case fatality rates of community-acquired pneumonia and pneumococcal diseases among Korean adults: Catchment population-based analysis

BACKGROUND: Pneumonia is a leading infectious cause of morbidity and mortality among adults. Pneumococcal pneumonia (PP) is the most common vaccine-preventable bacterial etiology of pneumonia. In this study, we estimated the incidence of community-acquired pneumonia (CAP) and pneumococcal diseases a...

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Autores principales: Heo, Jung Yeon, Seo, Yu Bin, Choi, Won Suk, Lee, Jacob, Yoon, Jin Gu, Lee, Saem Na, Choi, Min Joo, Noh, Ji Yun, Ahn, Jin-Young, Jeong, Hye Won, Cheong, Hee Jin, Kim, Woo Joo, Lee, Hee Young, Song, Joon Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875769/
https://www.ncbi.nlm.nih.gov/pubmed/29596444
http://dx.doi.org/10.1371/journal.pone.0194598
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author Heo, Jung Yeon
Seo, Yu Bin
Choi, Won Suk
Lee, Jacob
Yoon, Jin Gu
Lee, Saem Na
Choi, Min Joo
Noh, Ji Yun
Ahn, Jin-Young
Jeong, Hye Won
Cheong, Hee Jin
Kim, Woo Joo
Lee, Hee Young
Song, Joon Young
author_facet Heo, Jung Yeon
Seo, Yu Bin
Choi, Won Suk
Lee, Jacob
Yoon, Jin Gu
Lee, Saem Na
Choi, Min Joo
Noh, Ji Yun
Ahn, Jin-Young
Jeong, Hye Won
Cheong, Hee Jin
Kim, Woo Joo
Lee, Hee Young
Song, Joon Young
author_sort Heo, Jung Yeon
collection PubMed
description BACKGROUND: Pneumonia is a leading infectious cause of morbidity and mortality among adults. Pneumococcal pneumonia (PP) is the most common vaccine-preventable bacterial etiology of pneumonia. In this study, we estimated the incidence of community-acquired pneumonia (CAP) and pneumococcal diseases among Korean adults. METHODS: Clinical and microbiological databases from three hospitals were retrospectively reviewed to determine the incidence and case fatality rates of CAP and pneumococcal diseases in Korean adults aged ≥19 years from 2011 to 2014. Incidence and case fatality rates of CAP, PP and invasive pneumococcal diseases (IPD) were evaluated based on the catchment population. Catchment population was calculated using national health insurance data, estimating the proportion of patients with pneumonia that were medically attended at each hospital. RESULTS: Among 5,783 patients with medically attended CAP, 833 (14.4%) had PP. For IPD, a total of 91 culture-confirmed cases were identified. The overall incidence of CAP was 307.7 cases per 100,000 persons per year with an in-hospital mortality rate of 6.2%. The estimated annual incidence of pneumococcal pneumonia was 42.2–49.4 cases per 100,000 persons per year, increasing with age to >280 per 100,000 persons per year in older patients over 70 years. The annual incidence of IPD had a range of 4.1–6.5 cases per 100,000 persons per year. The overall case fatality rate for invasive pneumococcal diseases was 30.8% with the highest rate of 66.7% in patients over 80 years. CONCLUSION: Over the study period, incidences of CAP, PP and IPD were consistently high, particularly in older people. These results provide baseline data to establish healthcare strategies and estimate their impact among Korean adults.
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spelling pubmed-58757692018-04-13 Incidence and case fatality rates of community-acquired pneumonia and pneumococcal diseases among Korean adults: Catchment population-based analysis Heo, Jung Yeon Seo, Yu Bin Choi, Won Suk Lee, Jacob Yoon, Jin Gu Lee, Saem Na Choi, Min Joo Noh, Ji Yun Ahn, Jin-Young Jeong, Hye Won Cheong, Hee Jin Kim, Woo Joo Lee, Hee Young Song, Joon Young PLoS One Research Article BACKGROUND: Pneumonia is a leading infectious cause of morbidity and mortality among adults. Pneumococcal pneumonia (PP) is the most common vaccine-preventable bacterial etiology of pneumonia. In this study, we estimated the incidence of community-acquired pneumonia (CAP) and pneumococcal diseases among Korean adults. METHODS: Clinical and microbiological databases from three hospitals were retrospectively reviewed to determine the incidence and case fatality rates of CAP and pneumococcal diseases in Korean adults aged ≥19 years from 2011 to 2014. Incidence and case fatality rates of CAP, PP and invasive pneumococcal diseases (IPD) were evaluated based on the catchment population. Catchment population was calculated using national health insurance data, estimating the proportion of patients with pneumonia that were medically attended at each hospital. RESULTS: Among 5,783 patients with medically attended CAP, 833 (14.4%) had PP. For IPD, a total of 91 culture-confirmed cases were identified. The overall incidence of CAP was 307.7 cases per 100,000 persons per year with an in-hospital mortality rate of 6.2%. The estimated annual incidence of pneumococcal pneumonia was 42.2–49.4 cases per 100,000 persons per year, increasing with age to >280 per 100,000 persons per year in older patients over 70 years. The annual incidence of IPD had a range of 4.1–6.5 cases per 100,000 persons per year. The overall case fatality rate for invasive pneumococcal diseases was 30.8% with the highest rate of 66.7% in patients over 80 years. CONCLUSION: Over the study period, incidences of CAP, PP and IPD were consistently high, particularly in older people. These results provide baseline data to establish healthcare strategies and estimate their impact among Korean adults. Public Library of Science 2018-03-29 /pmc/articles/PMC5875769/ /pubmed/29596444 http://dx.doi.org/10.1371/journal.pone.0194598 Text en © 2018 Heo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Heo, Jung Yeon
Seo, Yu Bin
Choi, Won Suk
Lee, Jacob
Yoon, Jin Gu
Lee, Saem Na
Choi, Min Joo
Noh, Ji Yun
Ahn, Jin-Young
Jeong, Hye Won
Cheong, Hee Jin
Kim, Woo Joo
Lee, Hee Young
Song, Joon Young
Incidence and case fatality rates of community-acquired pneumonia and pneumococcal diseases among Korean adults: Catchment population-based analysis
title Incidence and case fatality rates of community-acquired pneumonia and pneumococcal diseases among Korean adults: Catchment population-based analysis
title_full Incidence and case fatality rates of community-acquired pneumonia and pneumococcal diseases among Korean adults: Catchment population-based analysis
title_fullStr Incidence and case fatality rates of community-acquired pneumonia and pneumococcal diseases among Korean adults: Catchment population-based analysis
title_full_unstemmed Incidence and case fatality rates of community-acquired pneumonia and pneumococcal diseases among Korean adults: Catchment population-based analysis
title_short Incidence and case fatality rates of community-acquired pneumonia and pneumococcal diseases among Korean adults: Catchment population-based analysis
title_sort incidence and case fatality rates of community-acquired pneumonia and pneumococcal diseases among korean adults: catchment population-based analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875769/
https://www.ncbi.nlm.nih.gov/pubmed/29596444
http://dx.doi.org/10.1371/journal.pone.0194598
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