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Sensitivity of different MRI sequences in the early detection of melanoma brain metastases
BACKGROUND: After the emergence of new MRI techniques such as susceptibility- and diffusion-weighted imaging (SWI and DWI) and because of specific imaging characteristics of melanoma brain metastases (MBM), it is unclear which MRI sequences are most beneficial for detection of MBM. This study was pe...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875773/ https://www.ncbi.nlm.nih.gov/pubmed/29596475 http://dx.doi.org/10.1371/journal.pone.0193946 |
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author | Deike-Hofmann, Katerina Thünemann, Daniel Breckwoldt, Michael O. Schwarz, Daniel Radbruch, Alexander Enk, Alexander Bendszus, Martin Hassel, Jessica Schlemmer, Heinz-Peter Bäumer, Philipp |
author_facet | Deike-Hofmann, Katerina Thünemann, Daniel Breckwoldt, Michael O. Schwarz, Daniel Radbruch, Alexander Enk, Alexander Bendszus, Martin Hassel, Jessica Schlemmer, Heinz-Peter Bäumer, Philipp |
author_sort | Deike-Hofmann, Katerina |
collection | PubMed |
description | BACKGROUND: After the emergence of new MRI techniques such as susceptibility- and diffusion-weighted imaging (SWI and DWI) and because of specific imaging characteristics of melanoma brain metastases (MBM), it is unclear which MRI sequences are most beneficial for detection of MBM. This study was performed to investigate the sensitivity of six clinical MRI sequences in the early detection of MBM. METHODS: Medical records of all melanoma patients referred to our center between November 2005 and December 2016 were reviewed for presence of MBM. Analysis encompassed six MRI sequences at the time of initial diagnosis of first or new MBM, including non-enhanced T1-weighted (T1w), contrast-enhanced T1w (ceT1w), T2-weighted (T2w), T2w-FLAIR, susceptibility-weighted (SWI) and diffusion-weighted (DWI) MRI. Each lesion was rated with respect to its conspicuity (score from 0—not detectable to 3—clearly visible). RESULTS: Of 1210 patients, 217 with MBM were included in the analysis and up to 5 lesions per patient were evaluated. A total of 720 metastases were assessed and all six sequences were available for 425 MBM. Sensitivity (conspicuity ≥2) was 99.7% for ceT1w, 77.0% for FLAIR, 64.7% for SWI, 61.0% for T2w, 56.7% for T1w, and 48.4% for DWI. Thirty-one (7.3%) of 425 lesions were only detectable by ceT1w but no other sequence. CONCLUSIONS: Contrast-enhanced T1-weighting is more sensitive than all other sequences for detection of MBM. Disruption of the blood-brain-barrier is consistently an earlier sign in MBM than perifocal edema, signal loss on SWI or diffusion restriction. |
format | Online Article Text |
id | pubmed-5875773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-58757732018-04-13 Sensitivity of different MRI sequences in the early detection of melanoma brain metastases Deike-Hofmann, Katerina Thünemann, Daniel Breckwoldt, Michael O. Schwarz, Daniel Radbruch, Alexander Enk, Alexander Bendszus, Martin Hassel, Jessica Schlemmer, Heinz-Peter Bäumer, Philipp PLoS One Research Article BACKGROUND: After the emergence of new MRI techniques such as susceptibility- and diffusion-weighted imaging (SWI and DWI) and because of specific imaging characteristics of melanoma brain metastases (MBM), it is unclear which MRI sequences are most beneficial for detection of MBM. This study was performed to investigate the sensitivity of six clinical MRI sequences in the early detection of MBM. METHODS: Medical records of all melanoma patients referred to our center between November 2005 and December 2016 were reviewed for presence of MBM. Analysis encompassed six MRI sequences at the time of initial diagnosis of first or new MBM, including non-enhanced T1-weighted (T1w), contrast-enhanced T1w (ceT1w), T2-weighted (T2w), T2w-FLAIR, susceptibility-weighted (SWI) and diffusion-weighted (DWI) MRI. Each lesion was rated with respect to its conspicuity (score from 0—not detectable to 3—clearly visible). RESULTS: Of 1210 patients, 217 with MBM were included in the analysis and up to 5 lesions per patient were evaluated. A total of 720 metastases were assessed and all six sequences were available for 425 MBM. Sensitivity (conspicuity ≥2) was 99.7% for ceT1w, 77.0% for FLAIR, 64.7% for SWI, 61.0% for T2w, 56.7% for T1w, and 48.4% for DWI. Thirty-one (7.3%) of 425 lesions were only detectable by ceT1w but no other sequence. CONCLUSIONS: Contrast-enhanced T1-weighting is more sensitive than all other sequences for detection of MBM. Disruption of the blood-brain-barrier is consistently an earlier sign in MBM than perifocal edema, signal loss on SWI or diffusion restriction. Public Library of Science 2018-03-29 /pmc/articles/PMC5875773/ /pubmed/29596475 http://dx.doi.org/10.1371/journal.pone.0193946 Text en © 2018 Deike-Hofmann et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Deike-Hofmann, Katerina Thünemann, Daniel Breckwoldt, Michael O. Schwarz, Daniel Radbruch, Alexander Enk, Alexander Bendszus, Martin Hassel, Jessica Schlemmer, Heinz-Peter Bäumer, Philipp Sensitivity of different MRI sequences in the early detection of melanoma brain metastases |
title | Sensitivity of different MRI sequences in the early detection of melanoma brain metastases |
title_full | Sensitivity of different MRI sequences in the early detection of melanoma brain metastases |
title_fullStr | Sensitivity of different MRI sequences in the early detection of melanoma brain metastases |
title_full_unstemmed | Sensitivity of different MRI sequences in the early detection of melanoma brain metastases |
title_short | Sensitivity of different MRI sequences in the early detection of melanoma brain metastases |
title_sort | sensitivity of different mri sequences in the early detection of melanoma brain metastases |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875773/ https://www.ncbi.nlm.nih.gov/pubmed/29596475 http://dx.doi.org/10.1371/journal.pone.0193946 |
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