Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer

Given the frequency with which MAP kinase signaling is dysregulated in cancer, much effort has been focused on inhibiting RAS signaling for therapeutic benefit. KSR1, a pseudokinase that interacts with RAF, is a potential target; it was originally cloned in screens for suppressors of constitutively...

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Detalles Bibliográficos
Autores principales: Germino, Elizabeth A., Miller, Joseph P., Diehl, Lauri, Swanson, Carter J., Durinck, Steffen, Modrusan, Zora, Miner, Jeffrey H., Shaw, Andrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875795/
https://www.ncbi.nlm.nih.gov/pubmed/29596465
http://dx.doi.org/10.1371/journal.pone.0194998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875795/
https://www.ncbi.nlm.nih.gov/pubmed/29596465
http://dx.doi.org/10.1371/journal.pone.0194998

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