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Volumetric‐modulated arc therapy and intensity‐modulated radiation therapy treatment planning for prostate cancer with flattened beam and flattening filter free linear accelerators

This study on patients with localized prostate cancer was set up to investigate valuable differences using flattened beam (FB) and flattening filter free (FFF) mode in the application of intensity‐modulated radiotherapy (IMRT) and volumetric‐modulated arc therapy (VMAT). For ten patients, four diffe...

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Autores principales: Treutwein, Marius, Hipp, Matthias, Koelbl, Oliver, Dobler, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875831/
https://www.ncbi.nlm.nih.gov/pubmed/28857432
http://dx.doi.org/10.1002/acm2.12168
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author Treutwein, Marius
Hipp, Matthias
Koelbl, Oliver
Dobler, Barbara
author_facet Treutwein, Marius
Hipp, Matthias
Koelbl, Oliver
Dobler, Barbara
author_sort Treutwein, Marius
collection PubMed
description This study on patients with localized prostate cancer was set up to investigate valuable differences using flattened beam (FB) and flattening filter free (FFF) mode in the application of intensity‐modulated radiotherapy (IMRT) and volumetric‐modulated arc therapy (VMAT). For ten patients, four different plans were calculated with Oncentra planning system of Elekta, using Synergy machines: IMRT and VMAT, with and without flattening filter. Homogeneity and conformity indexes, dose to the organs at risk, and measurements of peripheral dose and dosimetric plan verification including record of the delivery times were analyzed and statistically evaluated. The indexes for homogeneity and conformity (CTV and PTV) are either advantageous or not significantly different for FFF compared to FB with one minor exception. Regarding the doses to the organs at risk and the measured peripheral dose, equivalent or lower doses were delivered for FFF than with FB. Furthermore, the delivery times were significantly shorter for FFF. VMAT compared to IMRT reveals benefits or at least equivalent values. VMAT‐FFF combines the most advantageous plan quality parameters with the shortest delivery times and reduced peripheral dose and is therefore recommended for the given equipment and cancer localization.
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spelling pubmed-58758312018-04-02 Volumetric‐modulated arc therapy and intensity‐modulated radiation therapy treatment planning for prostate cancer with flattened beam and flattening filter free linear accelerators Treutwein, Marius Hipp, Matthias Koelbl, Oliver Dobler, Barbara J Appl Clin Med Phys Radiation Oncology Physics This study on patients with localized prostate cancer was set up to investigate valuable differences using flattened beam (FB) and flattening filter free (FFF) mode in the application of intensity‐modulated radiotherapy (IMRT) and volumetric‐modulated arc therapy (VMAT). For ten patients, four different plans were calculated with Oncentra planning system of Elekta, using Synergy machines: IMRT and VMAT, with and without flattening filter. Homogeneity and conformity indexes, dose to the organs at risk, and measurements of peripheral dose and dosimetric plan verification including record of the delivery times were analyzed and statistically evaluated. The indexes for homogeneity and conformity (CTV and PTV) are either advantageous or not significantly different for FFF compared to FB with one minor exception. Regarding the doses to the organs at risk and the measured peripheral dose, equivalent or lower doses were delivered for FFF than with FB. Furthermore, the delivery times were significantly shorter for FFF. VMAT compared to IMRT reveals benefits or at least equivalent values. VMAT‐FFF combines the most advantageous plan quality parameters with the shortest delivery times and reduced peripheral dose and is therefore recommended for the given equipment and cancer localization. John Wiley and Sons Inc. 2017-08-30 /pmc/articles/PMC5875831/ /pubmed/28857432 http://dx.doi.org/10.1002/acm2.12168 Text en © 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Treutwein, Marius
Hipp, Matthias
Koelbl, Oliver
Dobler, Barbara
Volumetric‐modulated arc therapy and intensity‐modulated radiation therapy treatment planning for prostate cancer with flattened beam and flattening filter free linear accelerators
title Volumetric‐modulated arc therapy and intensity‐modulated radiation therapy treatment planning for prostate cancer with flattened beam and flattening filter free linear accelerators
title_full Volumetric‐modulated arc therapy and intensity‐modulated radiation therapy treatment planning for prostate cancer with flattened beam and flattening filter free linear accelerators
title_fullStr Volumetric‐modulated arc therapy and intensity‐modulated radiation therapy treatment planning for prostate cancer with flattened beam and flattening filter free linear accelerators
title_full_unstemmed Volumetric‐modulated arc therapy and intensity‐modulated radiation therapy treatment planning for prostate cancer with flattened beam and flattening filter free linear accelerators
title_short Volumetric‐modulated arc therapy and intensity‐modulated radiation therapy treatment planning for prostate cancer with flattened beam and flattening filter free linear accelerators
title_sort volumetric‐modulated arc therapy and intensity‐modulated radiation therapy treatment planning for prostate cancer with flattened beam and flattening filter free linear accelerators
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875831/
https://www.ncbi.nlm.nih.gov/pubmed/28857432
http://dx.doi.org/10.1002/acm2.12168
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