A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells

Aging is a complex biological process, which determines the life span of an organism. Insulin-like growth factor (IGF) and Wnt signaling pathways govern the process of aging. Both pathways share common downstream targets that allow competitive crosstalk between these branches. Of note, a shift from...

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Autores principales: Siegle, Lea, Schwab, Julian D., Kühlwein, Silke D., Lausser, Ludwig, Tümpel, Stefan, Pfister, Astrid S., Kühl, Michael, Kestler, Hans A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875862/
https://www.ncbi.nlm.nih.gov/pubmed/29596489
http://dx.doi.org/10.1371/journal.pone.0195126
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author Siegle, Lea
Schwab, Julian D.
Kühlwein, Silke D.
Lausser, Ludwig
Tümpel, Stefan
Pfister, Astrid S.
Kühl, Michael
Kestler, Hans A.
author_facet Siegle, Lea
Schwab, Julian D.
Kühlwein, Silke D.
Lausser, Ludwig
Tümpel, Stefan
Pfister, Astrid S.
Kühl, Michael
Kestler, Hans A.
author_sort Siegle, Lea
collection PubMed
description Aging is a complex biological process, which determines the life span of an organism. Insulin-like growth factor (IGF) and Wnt signaling pathways govern the process of aging. Both pathways share common downstream targets that allow competitive crosstalk between these branches. Of note, a shift from IGF to Wnt signaling has been observed during aging of satellite cells. Biological regulatory networks necessary to recreate aging have not yet been discovered. Here, we established a mathematical in silico model that robustly recapitulates the crosstalk between IGF and Wnt signaling. Strikingly, it predicts critical nodes following a shift from IGF to Wnt signaling. These findings indicate that this shift might cause age-related diseases.
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spelling pubmed-58758622018-04-13 A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells Siegle, Lea Schwab, Julian D. Kühlwein, Silke D. Lausser, Ludwig Tümpel, Stefan Pfister, Astrid S. Kühl, Michael Kestler, Hans A. PLoS One Research Article Aging is a complex biological process, which determines the life span of an organism. Insulin-like growth factor (IGF) and Wnt signaling pathways govern the process of aging. Both pathways share common downstream targets that allow competitive crosstalk between these branches. Of note, a shift from IGF to Wnt signaling has been observed during aging of satellite cells. Biological regulatory networks necessary to recreate aging have not yet been discovered. Here, we established a mathematical in silico model that robustly recapitulates the crosstalk between IGF and Wnt signaling. Strikingly, it predicts critical nodes following a shift from IGF to Wnt signaling. These findings indicate that this shift might cause age-related diseases. Public Library of Science 2018-03-29 /pmc/articles/PMC5875862/ /pubmed/29596489 http://dx.doi.org/10.1371/journal.pone.0195126 Text en © 2018 Siegle et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Siegle, Lea
Schwab, Julian D.
Kühlwein, Silke D.
Lausser, Ludwig
Tümpel, Stefan
Pfister, Astrid S.
Kühl, Michael
Kestler, Hans A.
A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells
title A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells
title_full A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells
title_fullStr A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells
title_full_unstemmed A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells
title_short A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells
title_sort boolean network of the crosstalk between igf and wnt signaling in aging satellite cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875862/
https://www.ncbi.nlm.nih.gov/pubmed/29596489
http://dx.doi.org/10.1371/journal.pone.0195126
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