Cargando…

The Association between Fat Mass, Lean Mass and Bone Mineral Density in Premenopausal Women in Korea: A Cross-Sectional Study

BACKGROUND: We investigated the association between body composition, especially truncal or non-truncal fat mass (FM), and bone mineral density (BMD) in premenopausal women in Korea. METHODS: A cross-sectional study was performed using data from the Korea National Health and Nutrition Examination Su...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Jeehyun, Kwon, Hyuktae, Heo, Bo-Kyoung, Joh, Hee-Kyung, Lee, Cheol Min, Hwang, Seung-Sik, Park, Danbee, Park, Jae-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Family Medicine 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876052/
https://www.ncbi.nlm.nih.gov/pubmed/29629038
http://dx.doi.org/10.4082/kjfm.2018.39.2.74
_version_ 1783310453920759808
author Kim, Jeehyun
Kwon, Hyuktae
Heo, Bo-Kyoung
Joh, Hee-Kyung
Lee, Cheol Min
Hwang, Seung-Sik
Park, Danbee
Park, Jae-Hong
author_facet Kim, Jeehyun
Kwon, Hyuktae
Heo, Bo-Kyoung
Joh, Hee-Kyung
Lee, Cheol Min
Hwang, Seung-Sik
Park, Danbee
Park, Jae-Hong
author_sort Kim, Jeehyun
collection PubMed
description BACKGROUND: We investigated the association between body composition, especially truncal or non-truncal fat mass (FM), and bone mineral density (BMD) in premenopausal women in Korea. METHODS: A cross-sectional study was performed using data from the Korea National Health and Nutrition Examination Survey IV and V (2008–2011). Total lean mass (LM), total FM (TFM), truncal FM, and non-truncal FM, and BMD of the total femur, femoral neck (FN), and lumbar spine were measured using dual-energy X-ray absorptiometry. The association between body composition and BMD was analyzed using multiple linear regression. The risk of low BMD according to quartiles of TFM, truncal FM, and non-truncal FM was calculated using logistic regression. Subgroup analysis according to body mass index was also performed. RESULTS: In 4,343 premenopausal women, total LM was positively associated with BMD regardless of weight adjustment. TFM, truncal FM, and non-truncal FM were inversely associated with BMD after adjusting for weight. Odds ratios (ORs) for low BMD and 95% confidence intervals (CIs) of the highest quartile of TFM, truncal FM, and non-truncal FM compared with the lowest quartile were calculated. The risk of low BMD of the FN was higher in the highest quartile of TFM (OR, 4.48; 95% CI, 1.11–18.01) and truncal FM (OR, 5.48; 95% CI, 1.75–17.20). Truncal FM and not-truncal FM had an inverse association with BMD in the non-obese and obese subgroups of women. CONCLUSION: Total LM has a protective effect on BMD and FM can have a detrimental effect on BMD besides its skeletal loading effect.
format Online
Article
Text
id pubmed-5876052
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher The Korean Academy of Family Medicine
record_format MEDLINE/PubMed
spelling pubmed-58760522018-04-06 The Association between Fat Mass, Lean Mass and Bone Mineral Density in Premenopausal Women in Korea: A Cross-Sectional Study Kim, Jeehyun Kwon, Hyuktae Heo, Bo-Kyoung Joh, Hee-Kyung Lee, Cheol Min Hwang, Seung-Sik Park, Danbee Park, Jae-Hong Korean J Fam Med Original Article BACKGROUND: We investigated the association between body composition, especially truncal or non-truncal fat mass (FM), and bone mineral density (BMD) in premenopausal women in Korea. METHODS: A cross-sectional study was performed using data from the Korea National Health and Nutrition Examination Survey IV and V (2008–2011). Total lean mass (LM), total FM (TFM), truncal FM, and non-truncal FM, and BMD of the total femur, femoral neck (FN), and lumbar spine were measured using dual-energy X-ray absorptiometry. The association between body composition and BMD was analyzed using multiple linear regression. The risk of low BMD according to quartiles of TFM, truncal FM, and non-truncal FM was calculated using logistic regression. Subgroup analysis according to body mass index was also performed. RESULTS: In 4,343 premenopausal women, total LM was positively associated with BMD regardless of weight adjustment. TFM, truncal FM, and non-truncal FM were inversely associated with BMD after adjusting for weight. Odds ratios (ORs) for low BMD and 95% confidence intervals (CIs) of the highest quartile of TFM, truncal FM, and non-truncal FM compared with the lowest quartile were calculated. The risk of low BMD of the FN was higher in the highest quartile of TFM (OR, 4.48; 95% CI, 1.11–18.01) and truncal FM (OR, 5.48; 95% CI, 1.75–17.20). Truncal FM and not-truncal FM had an inverse association with BMD in the non-obese and obese subgroups of women. CONCLUSION: Total LM has a protective effect on BMD and FM can have a detrimental effect on BMD besides its skeletal loading effect. The Korean Academy of Family Medicine 2018-03 2018-03-22 /pmc/articles/PMC5876052/ /pubmed/29629038 http://dx.doi.org/10.4082/kjfm.2018.39.2.74 Text en Copyright © 2018 The Korean Academy of Family Medicine http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Jeehyun
Kwon, Hyuktae
Heo, Bo-Kyoung
Joh, Hee-Kyung
Lee, Cheol Min
Hwang, Seung-Sik
Park, Danbee
Park, Jae-Hong
The Association between Fat Mass, Lean Mass and Bone Mineral Density in Premenopausal Women in Korea: A Cross-Sectional Study
title The Association between Fat Mass, Lean Mass and Bone Mineral Density in Premenopausal Women in Korea: A Cross-Sectional Study
title_full The Association between Fat Mass, Lean Mass and Bone Mineral Density in Premenopausal Women in Korea: A Cross-Sectional Study
title_fullStr The Association between Fat Mass, Lean Mass and Bone Mineral Density in Premenopausal Women in Korea: A Cross-Sectional Study
title_full_unstemmed The Association between Fat Mass, Lean Mass and Bone Mineral Density in Premenopausal Women in Korea: A Cross-Sectional Study
title_short The Association between Fat Mass, Lean Mass and Bone Mineral Density in Premenopausal Women in Korea: A Cross-Sectional Study
title_sort association between fat mass, lean mass and bone mineral density in premenopausal women in korea: a cross-sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876052/
https://www.ncbi.nlm.nih.gov/pubmed/29629038
http://dx.doi.org/10.4082/kjfm.2018.39.2.74
work_keys_str_mv AT kimjeehyun theassociationbetweenfatmassleanmassandbonemineraldensityinpremenopausalwomeninkoreaacrosssectionalstudy
AT kwonhyuktae theassociationbetweenfatmassleanmassandbonemineraldensityinpremenopausalwomeninkoreaacrosssectionalstudy
AT heobokyoung theassociationbetweenfatmassleanmassandbonemineraldensityinpremenopausalwomeninkoreaacrosssectionalstudy
AT johheekyung theassociationbetweenfatmassleanmassandbonemineraldensityinpremenopausalwomeninkoreaacrosssectionalstudy
AT leecheolmin theassociationbetweenfatmassleanmassandbonemineraldensityinpremenopausalwomeninkoreaacrosssectionalstudy
AT hwangseungsik theassociationbetweenfatmassleanmassandbonemineraldensityinpremenopausalwomeninkoreaacrosssectionalstudy
AT parkdanbee theassociationbetweenfatmassleanmassandbonemineraldensityinpremenopausalwomeninkoreaacrosssectionalstudy
AT parkjaehong theassociationbetweenfatmassleanmassandbonemineraldensityinpremenopausalwomeninkoreaacrosssectionalstudy
AT kimjeehyun associationbetweenfatmassleanmassandbonemineraldensityinpremenopausalwomeninkoreaacrosssectionalstudy
AT kwonhyuktae associationbetweenfatmassleanmassandbonemineraldensityinpremenopausalwomeninkoreaacrosssectionalstudy
AT heobokyoung associationbetweenfatmassleanmassandbonemineraldensityinpremenopausalwomeninkoreaacrosssectionalstudy
AT johheekyung associationbetweenfatmassleanmassandbonemineraldensityinpremenopausalwomeninkoreaacrosssectionalstudy
AT leecheolmin associationbetweenfatmassleanmassandbonemineraldensityinpremenopausalwomeninkoreaacrosssectionalstudy
AT hwangseungsik associationbetweenfatmassleanmassandbonemineraldensityinpremenopausalwomeninkoreaacrosssectionalstudy
AT parkdanbee associationbetweenfatmassleanmassandbonemineraldensityinpremenopausalwomeninkoreaacrosssectionalstudy
AT parkjaehong associationbetweenfatmassleanmassandbonemineraldensityinpremenopausalwomeninkoreaacrosssectionalstudy