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SAHA (Vorinostat) Corrects Inhibitory Synaptic Deficits Caused by Missense Epilepsy Mutations to the GABA(A) Receptor γ2 Subunit

The GABA(A) receptor (GABA(A)R) α1 subunit A295D epilepsy mutation reduces the surface expression of α1(A295D)β2γ2 GABA(A)Rs via ER-associated protein degradation. Suberanilohydroxamic acid (SAHA, also known as Vorinostat) was recently shown to correct the misfolding of α1(A295D) subunits and thereb...

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Detalles Bibliográficos
Autores principales:	Durisic, Nela, Keramidas, Angelo, Dixon, Christine L., Lynch, Joseph W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876238/ https://www.ncbi.nlm.nih.gov/pubmed/29628874 http://dx.doi.org/10.3389/fnmol.2018.00089

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