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Anti-gout Potential of Malaysian Medicinal Plants
Gout is a type of arthritis that causes painful inflammation in one or more joints. In gout, elevation of uric acid in the blood triggers the formation of crystals, causing joint pain. Malaysia is a mega-biodiversity country that is rich in medicinal plants species. Therefore, its flora might offer...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876239/ https://www.ncbi.nlm.nih.gov/pubmed/29628890 http://dx.doi.org/10.3389/fphar.2018.00261 |
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author | Abu Bakar, Fazleen I. Abu Bakar, Mohd F. Rahmat, Asmah Abdullah, Norazlin Sabran, Siti F. Endrini, Susi |
author_facet | Abu Bakar, Fazleen I. Abu Bakar, Mohd F. Rahmat, Asmah Abdullah, Norazlin Sabran, Siti F. Endrini, Susi |
author_sort | Abu Bakar, Fazleen I. |
collection | PubMed |
description | Gout is a type of arthritis that causes painful inflammation in one or more joints. In gout, elevation of uric acid in the blood triggers the formation of crystals, causing joint pain. Malaysia is a mega-biodiversity country that is rich in medicinal plants species. Therefore, its flora might offer promising therapies for gout. This article aims to systematically review the anti-gout potential of Malaysian medicinal plants. Articles on gout published from 2000 to 2017 were identified using PubMed, Scopus, ScienceDirect, and Google Scholar with the following keyword search terms: “gout,” “medicinal plants,” “Malaysia,” “epidemiology,” “in vitro,” and “in vivo.” In this study, 85 plants were identified as possessing anti-gout activity. These plants had higher percentages of xanthine oxidase inhibitory activity (>85%); specifically, the Momordica charantia, Chrysanthemum indicum, Cinnamomum cassia, Kaempferia galanga, Artemisia vulgaris, and Morinda elliptica had the highest values, due to their diverse natural bioactive compounds, which include flavonoids, phenolics, tannin, coumarins, luteolin, and apigenin. This review summarizes the anti-gout potential of Malaysian medicinal plants but the mechanisms, active compounds, pharmacokinetics, bioavailability, and safety of the plants still remain to be elucidated. |
format | Online Article Text |
id | pubmed-5876239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58762392018-04-06 Anti-gout Potential of Malaysian Medicinal Plants Abu Bakar, Fazleen I. Abu Bakar, Mohd F. Rahmat, Asmah Abdullah, Norazlin Sabran, Siti F. Endrini, Susi Front Pharmacol Pharmacology Gout is a type of arthritis that causes painful inflammation in one or more joints. In gout, elevation of uric acid in the blood triggers the formation of crystals, causing joint pain. Malaysia is a mega-biodiversity country that is rich in medicinal plants species. Therefore, its flora might offer promising therapies for gout. This article aims to systematically review the anti-gout potential of Malaysian medicinal plants. Articles on gout published from 2000 to 2017 were identified using PubMed, Scopus, ScienceDirect, and Google Scholar with the following keyword search terms: “gout,” “medicinal plants,” “Malaysia,” “epidemiology,” “in vitro,” and “in vivo.” In this study, 85 plants were identified as possessing anti-gout activity. These plants had higher percentages of xanthine oxidase inhibitory activity (>85%); specifically, the Momordica charantia, Chrysanthemum indicum, Cinnamomum cassia, Kaempferia galanga, Artemisia vulgaris, and Morinda elliptica had the highest values, due to their diverse natural bioactive compounds, which include flavonoids, phenolics, tannin, coumarins, luteolin, and apigenin. This review summarizes the anti-gout potential of Malaysian medicinal plants but the mechanisms, active compounds, pharmacokinetics, bioavailability, and safety of the plants still remain to be elucidated. Frontiers Media S.A. 2018-03-23 /pmc/articles/PMC5876239/ /pubmed/29628890 http://dx.doi.org/10.3389/fphar.2018.00261 Text en Copyright © 2018 Abu Bakar, Abu Bakar, Rahmat, Abdullah, Sabran and Endrini. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Abu Bakar, Fazleen I. Abu Bakar, Mohd F. Rahmat, Asmah Abdullah, Norazlin Sabran, Siti F. Endrini, Susi Anti-gout Potential of Malaysian Medicinal Plants |
title | Anti-gout Potential of Malaysian Medicinal Plants |
title_full | Anti-gout Potential of Malaysian Medicinal Plants |
title_fullStr | Anti-gout Potential of Malaysian Medicinal Plants |
title_full_unstemmed | Anti-gout Potential of Malaysian Medicinal Plants |
title_short | Anti-gout Potential of Malaysian Medicinal Plants |
title_sort | anti-gout potential of malaysian medicinal plants |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876239/ https://www.ncbi.nlm.nih.gov/pubmed/29628890 http://dx.doi.org/10.3389/fphar.2018.00261 |
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