Fibrolamellar Hepatocellular Carcinoma: Treatment with Yttrium-90 and Subsequent Surgical Resection

We describe a 52-year-old female patient who presented with a 9.5-cm fibrolamellar hepatocellular carcinoma (FL-HCC). The patient was initially unsuitable for surgical resection and therefore underwent transarterial chemoembolization followed by selective internal radiation therapy (SIRT) with Yttri...

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Autores principales: Mafeld, Sebastian, French, Jeremy, Tiniakos, Dina, Haugk, Beate, Manas, Derek, Littler, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876273/
https://www.ncbi.nlm.nih.gov/pubmed/29468286
http://dx.doi.org/10.1007/s00270-018-1903-6
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author Mafeld, Sebastian
French, Jeremy
Tiniakos, Dina
Haugk, Beate
Manas, Derek
Littler, Peter
author_facet Mafeld, Sebastian
French, Jeremy
Tiniakos, Dina
Haugk, Beate
Manas, Derek
Littler, Peter
author_sort Mafeld, Sebastian
collection PubMed
description We describe a 52-year-old female patient who presented with a 9.5-cm fibrolamellar hepatocellular carcinoma (FL-HCC). The patient was initially unsuitable for surgical resection and therefore underwent transarterial chemoembolization followed by selective internal radiation therapy (SIRT) with Yttrium-90 to downsize the tumour. Following SIRT, the tumour decreased in volume from 350 to 20 cm(3) allowing curative (R0) resection with an extended left hepatectomy and reconstruction of IVC. This is the first reported case of FL-HCC treated with SIRT in which, due to the good SIRT response, the patient was downsized to allow curative resection.
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spelling pubmed-58762732018-04-03 Fibrolamellar Hepatocellular Carcinoma: Treatment with Yttrium-90 and Subsequent Surgical Resection Mafeld, Sebastian French, Jeremy Tiniakos, Dina Haugk, Beate Manas, Derek Littler, Peter Cardiovasc Intervent Radiol Case Report We describe a 52-year-old female patient who presented with a 9.5-cm fibrolamellar hepatocellular carcinoma (FL-HCC). The patient was initially unsuitable for surgical resection and therefore underwent transarterial chemoembolization followed by selective internal radiation therapy (SIRT) with Yttrium-90 to downsize the tumour. Following SIRT, the tumour decreased in volume from 350 to 20 cm(3) allowing curative (R0) resection with an extended left hepatectomy and reconstruction of IVC. This is the first reported case of FL-HCC treated with SIRT in which, due to the good SIRT response, the patient was downsized to allow curative resection. Springer US 2018-02-21 2018 /pmc/articles/PMC5876273/ /pubmed/29468286 http://dx.doi.org/10.1007/s00270-018-1903-6 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Mafeld, Sebastian
French, Jeremy
Tiniakos, Dina
Haugk, Beate
Manas, Derek
Littler, Peter
Fibrolamellar Hepatocellular Carcinoma: Treatment with Yttrium-90 and Subsequent Surgical Resection
title Fibrolamellar Hepatocellular Carcinoma: Treatment with Yttrium-90 and Subsequent Surgical Resection
title_full Fibrolamellar Hepatocellular Carcinoma: Treatment with Yttrium-90 and Subsequent Surgical Resection
title_fullStr Fibrolamellar Hepatocellular Carcinoma: Treatment with Yttrium-90 and Subsequent Surgical Resection
title_full_unstemmed Fibrolamellar Hepatocellular Carcinoma: Treatment with Yttrium-90 and Subsequent Surgical Resection
title_short Fibrolamellar Hepatocellular Carcinoma: Treatment with Yttrium-90 and Subsequent Surgical Resection
title_sort fibrolamellar hepatocellular carcinoma: treatment with yttrium-90 and subsequent surgical resection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876273/
https://www.ncbi.nlm.nih.gov/pubmed/29468286
http://dx.doi.org/10.1007/s00270-018-1903-6
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