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Interaction of Glycolipids with the Macrophage Surface Receptor Mincle – a Systematic Molecular Dynamics Study

Synthetic analogues of mycobacterial trehalose-dimycolate such as trehalose acyl esters have been proposed as novel adjuvants for vaccination. They induce an immune response by binding to the macrophage C-type lectin receptor Mincle. The binding site of trehalose is known, but there is yet only very...

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Detalles Bibliográficos
Autores principales:	Söldner, Christian A., Horn, Anselm H. C., Sticht, Heinrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876379/ https://www.ncbi.nlm.nih.gov/pubmed/29599490 http://dx.doi.org/10.1038/s41598-018-23624-8

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