Cargando…

Hydroxycamptothecin mediates antiproliferative effects through apoptosis and autophagy in A549 cells

Hydroxycamptothecin (HCPT) represents a new generation of anticancer drugs, with almost no side effects when used for the treatment of a number of types of cancer. Autophagy is becoming recognized as an important biological mechanism in human cancer, including lung cancer. However, the involvement o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Yanjie, Li, Chenhao, Zhang, Yuan, He, Hailan, Zhang, Guozhi, Hao, Xiaohui, Liu, Heliang, Wang, Hongli, Tian, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876437/ https://www.ncbi.nlm.nih.gov/pubmed/29616109 http://dx.doi.org/10.3892/ol.2018.8107

Ejemplares similares

The role of activating transcription factor 6 in hydroxycamptothecin-induced fibroblast autophagy and apoptosis
por: Tao, Jin, et al.
Publicado: (2021)

Hydroxycamptothecin Inhibits Peritendinous Adhesion via the Endoplasmic Reticulum Stress-Dependent Apoptosis
por: Yao, Zhixiao, et al.
Publicado: (2019)

Combination treatment with triptolide and hydroxycamptothecin synergistically enhances apoptosis in A549 lung adenocarcinoma cells through PP2A-regulated ERK, p38 MAPKs and Akt signaling pathways
por: MENG, GUANMIN, et al.
Publicado: (2015)

Preparation and in vitro and in vivo evaluations of 10-hydroxycamptothecin liposomes modified with stearyl glycyrrhetinate
por: Zhou, Ting, et al.
Publicado: (2019)

Preparation, Characterization, and in vivo Evaluation of NK4-Conjugated Hydroxycamptothecin-Loaded Liposomes
por: Zhou, Ting, et al.
Publicado: (2020)

Hydroxycamptothecin induces apoptosis and inhibits tumor growth in colon cancer by the downregulation of survivin and XIAP expression
por: Fei, Bojian, et al.
Publicado: (2013)

Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin
por: Chen, Yukun, et al.
Publicado: (2022)

Co-Prodrugs of 7-Ethyl-10-hydroxycamptothecin and Vorinostat with in Vitro Hydrolysis and Anticancer Effects
por: Liu, Shuangxi, et al.
Publicado: (2019)

Synthetic high-density lipoproteins for delivery of 10-hydroxycamptothecin
por: Yuan, Yue, et al.
Publicado: (2016)

Effect of verapamil on the pharmacokinetics of hydroxycamptothecin and its potential mechanism
por: Xing, Hua, et al.
Publicado: (2020)

Antitumor Mechanism of Hydroxycamptothecin via the Metabolic Perturbation of Ribonucleotide and Deoxyribonucleotide in Human Colorectal Carcinoma Cells
por: Li, Yan, et al.
Publicado: (2021)

Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 activation
por: Shi, Xiaolan, et al.
Publicado: (2018)

The effect of hydroxycamptothecin and pingyangmycin on human squamous cell carcinoma of the tongue
por: CHEN, PENG, et al.
Publicado: (2013)

The optimal concentration of topical hydroxycamptothecin in preventing intraarticular scar adhesion
por: Liang, Yuan, et al.
Publicado: (2014)

The Role of Glucuronidation in 7‐Ethyl‐10‐hydroxycamptothecin Resistance in vitro
por: Takahashi, Toshiaki, et al.
Publicado: (1997)

Upregulation of NOXA by 10-Hydroxycamptothecin plays a key role in inducing fibroblasts apoptosis and reducing epidural fibrosis
por: Dai, Jihang, et al.
Publicado: (2017)

10-Hydroxycamptothecin induces apoptosis in human fibroblasts by regulating miRNA-23b-3p expression
por: Zeng, Lingrong, et al.
Publicado: (2019)

Mitochondria-Mediated Apoptosis and Autophagy Participate in Buprofezin-Induced Toxic Effects in Non-Target A549 Cells
por: Ren, Yuanhang, et al.
Publicado: (2022)

Antiproliferative Effect of Aminoethyl-Chitooligosaccharide on Human Lung A549 Cancer Cells
por: Ngo, Dai Hung, et al.
Publicado: (2019)

miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated mTOR in SiO(2)-Induced Lung Fibrosis
por: Li, Peiyuan, et al.
Publicado: (2023)

Induction of ligustrazine apoptosis of A549 cells through activation of death receptor pathway
por: Zheng, Wei, et al.
Publicado: (2022)

Hydroxycamptothecin-loaded nanoparticles enhance target drug delivery and anticancer effect
por: Wang, Anxun, et al.
Publicado: (2008)

Effect of autophagy inhibition on chemotherapy-induced apoptosis in A549 lung cancer cells
por: LIU, FEIFEI, et al.
Publicado: (2013)

Naesohwangryeon-tang Induced Apoptosis and Autophagy in A549 Human Lung Cancer Cells
por: Kim, Hong Jae, et al.
Publicado: (2019)

Increased expression of DNA repair gene XPF enhances resistance to hydroxycamptothecin in bladder cancer
por: Li, Jie, et al.
Publicado: (2012)

Preparation and Physicochemical Properties of 10-Hydroxycamptothecin (HCPT) Nanoparticles by Supercritical Antisolvent (SAS) Process
por: Zhao, Xiuhua, et al.
Publicado: (2011)

Neddylation inhibitor MLN4924 sensitizes head and neck squamous carcinoma cells to (S)-10-hydroxycamptothecin
por: Gu, Shanshan, et al.
Publicado: (2023)

Antiproliferative and Proapoptotic Effects of Phenanthrene Derivatives Isolated from Bletilla striata on A549 Lung Cancer Cells
por: Zhou, Fei, et al.
Publicado: (2022)

Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells
por: Hao, Wenhui, et al.
Publicado: (2014)

Role of Raf-kinase inhibitor protein in colorectal cancer and its regulation by hydroxycamptothecine
por: Nie, Fang, et al.
Publicado: (2015)

Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy
por: Gao, Caifang, et al.
Publicado: (2019)

Interferon regulatory factor-1 regulates cisplatin-induced apoptosis and autophagy in A549 lung cancer cells
por: Zhang, Lemeng, et al.
Publicado: (2022)

New Imatinib Derivatives with Antiproliferative Activity against A549 and K562 Cancer Cells
por: Oliveira, Andressa, et al.
Publicado: (2022)

Chamaejasmine Induces Apoptosis in Human Lung Adenocarcinoma A549 Cells through a Ros-Mediated Mitochondrial Pathway
por: Yu, Hongyang, et al.
Publicado: (2011)

The effect of tetrandrine combined with cisplatin on proliferation and apoptosis of A549/DDP cells and A549 cells
por: Ye, Ling-Yun, et al.
Publicado: (2017)

Novel 2-Amino-1,4-Naphthoquinone Derivatives Induce A549 Cell Death through Autophagy
por: Tan, Hua-Yuan, et al.
Publicado: (2023)

Discovery of highly potent and selective 7-ethyl-10-hydroxycamptothecin-glucose conjugates as potential anti-colorectal cancer agents
por: Yang, Chao, et al.
Publicado: (2022)

Extracellular vesicles from hydroxycamptothecin primed umbilical cord stem cells enhance anti-adhesion potential for treatment of tendon injury
por: Li, Juehong, et al.
Publicado: (2020)

T-Type Ca(2+) Channel Blocker, KYS05090 Induces Autophagy and Apoptosis in A549 Cells through Inhibiting Glucose Uptake
por: Rim, Hong-Kun, et al.
Publicado: (2014)

Effects of nanoparticle size on antitumor activity of 10-hydroxycamptothecin-conjugated gold nanoparticles: in vitro and in vivo studies
por: Bao, Hanmei, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_g7n7k1isdo9n7e2e31va249phd