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Clinically Usable Interleukin 12 Plasmid without an Antibiotic Resistance Gene: Functionality and Toxicity Study in Murine Melanoma Model

Plasmids, which are currently used in interleukin 12 (IL-12) gene electrotransfer (GET) clinical trials in the USA, contain antibiotic resistance genes and are thus, according to the safety recommendation of the European Medicines Agency (EMA), not suitable for clinical trials in the EU. In the curr...

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Detalles Bibliográficos
Autores principales:	Kamensek, Urska, Tesic, Natasa, Sersa, Gregor, Cemazar, Maja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876635/ https://www.ncbi.nlm.nih.gov/pubmed/29495490 http://dx.doi.org/10.3390/cancers10030060

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