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Stereotactic Radiotherapy and Particle Therapy for Pancreatic Cancer

Pancreatic cancer is a devastating disease with poor survival outcomes. Recent studies have shown that the addition of radiotherapy to chemotherapy in the setting of locally advanced pancreatic cancer did not improve overall survival outcome. These studies commonly utilize conventional radiotherapy...

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Detalles Bibliográficos
Autores principales: Ng, Sweet Ping, Herman, Joseph M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876650/
https://www.ncbi.nlm.nih.gov/pubmed/29547526
http://dx.doi.org/10.3390/cancers10030075
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author Ng, Sweet Ping
Herman, Joseph M.
author_facet Ng, Sweet Ping
Herman, Joseph M.
author_sort Ng, Sweet Ping
collection PubMed
description Pancreatic cancer is a devastating disease with poor survival outcomes. Recent studies have shown that the addition of radiotherapy to chemotherapy in the setting of locally advanced pancreatic cancer did not improve overall survival outcome. These studies commonly utilize conventional radiotherapy treatment fractionation and technique (typically 3-D conformal radiotherapy or intensity modulated radiotherapy). Although no clear benefit in overall survival was demonstrated in those studies, those who received radiotherapy did have a clear benefit in terms of local control. Therefore, there is increasing interest in exploring different techniques and/or modality of radiotherapy and dose/fractionation. Stereotactic radiotherapy, which employs a hypofractionated regimen, has the potential advantage of delivering a high dose of radiation to the tumor in a short period of time (typically over 5 days) with minimal dose to the surrounding normal structures. Particle therapy such as proton and carbon ion therapy are being explored as potential radiation modality that could cause greater biological damage to the tumor compared to photon treatment, with rapid dose falloff resulting in minimal to no dose to adjacent structures. This review will discuss the current literature and emerging roles of stereotactic radiotherapy and particle therapy in pancreatic cancer.
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spelling pubmed-58766502018-04-09 Stereotactic Radiotherapy and Particle Therapy for Pancreatic Cancer Ng, Sweet Ping Herman, Joseph M. Cancers (Basel) Review Pancreatic cancer is a devastating disease with poor survival outcomes. Recent studies have shown that the addition of radiotherapy to chemotherapy in the setting of locally advanced pancreatic cancer did not improve overall survival outcome. These studies commonly utilize conventional radiotherapy treatment fractionation and technique (typically 3-D conformal radiotherapy or intensity modulated radiotherapy). Although no clear benefit in overall survival was demonstrated in those studies, those who received radiotherapy did have a clear benefit in terms of local control. Therefore, there is increasing interest in exploring different techniques and/or modality of radiotherapy and dose/fractionation. Stereotactic radiotherapy, which employs a hypofractionated regimen, has the potential advantage of delivering a high dose of radiation to the tumor in a short period of time (typically over 5 days) with minimal dose to the surrounding normal structures. Particle therapy such as proton and carbon ion therapy are being explored as potential radiation modality that could cause greater biological damage to the tumor compared to photon treatment, with rapid dose falloff resulting in minimal to no dose to adjacent structures. This review will discuss the current literature and emerging roles of stereotactic radiotherapy and particle therapy in pancreatic cancer. MDPI 2018-03-16 /pmc/articles/PMC5876650/ /pubmed/29547526 http://dx.doi.org/10.3390/cancers10030075 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ng, Sweet Ping
Herman, Joseph M.
Stereotactic Radiotherapy and Particle Therapy for Pancreatic Cancer
title Stereotactic Radiotherapy and Particle Therapy for Pancreatic Cancer
title_full Stereotactic Radiotherapy and Particle Therapy for Pancreatic Cancer
title_fullStr Stereotactic Radiotherapy and Particle Therapy for Pancreatic Cancer
title_full_unstemmed Stereotactic Radiotherapy and Particle Therapy for Pancreatic Cancer
title_short Stereotactic Radiotherapy and Particle Therapy for Pancreatic Cancer
title_sort stereotactic radiotherapy and particle therapy for pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876650/
https://www.ncbi.nlm.nih.gov/pubmed/29547526
http://dx.doi.org/10.3390/cancers10030075
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