Cancer dormancy and criticality from a game theory perspective

BACKGROUND: The physics of cancer dormancy, the time between initial cancer treatment and re-emergence after a protracted period, is a puzzle. Cancer cells interact with host cells via complex, non-linear population dynamics, which can lead to very non-intuitive but perhaps deterministic and underst...

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Detalles Bibliográficos
Autores principales: Wu, Amy, Liao, David, Kirilin, Vlamimir, Lin, Ke-Chih, Torga, Gonzalo, Qu, Junle, Liu, Liyu, Sturm, James C., Pienta, Kenneth, Austin, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876693/
https://www.ncbi.nlm.nih.gov/pubmed/29623956
http://dx.doi.org/10.1186/s41236-018-0008-0
Descripción
Sumario:BACKGROUND: The physics of cancer dormancy, the time between initial cancer treatment and re-emergence after a protracted period, is a puzzle. Cancer cells interact with host cells via complex, non-linear population dynamics, which can lead to very non-intuitive but perhaps deterministic and understandable progression dynamics of cancer and dormancy. RESULTS: We explore here the dynamics of host-cancer cell populations in the presence of (1) payoffs gradients and (2) perturbations due to cell migration. CONCLUSIONS: We determine to what extent the time-dependence of the populations can be quantitively understood in spite of the underlying complexity of the individual agents and model the phenomena of dormancy.

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