Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron

Sodium dodecyl sulphate-supported iron silicophosphate (SDS/FeSP) nanocomposite was successfully fabricated by the co-precipitation method. The SDS/FeSP nanocomposite was investigated as a drug carrier for ondansetron. The cumulative drug release of ondansetron was observed at various pH values for...

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Autores principales: Sharma, Gaurav, Naushad, Mu., Thakur, Bharti, Kumar, Amit, Negi, Poonam, Saini, Reena, Chahal, Anterpreet, Kumar, Ashok, Stadler, Florian J., Aqil, U.M.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876959/
https://www.ncbi.nlm.nih.gov/pubmed/29495530
http://dx.doi.org/10.3390/ijerph15030414
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author Sharma, Gaurav
Naushad, Mu.
Thakur, Bharti
Kumar, Amit
Negi, Poonam
Saini, Reena
Chahal, Anterpreet
Kumar, Ashok
Stadler, Florian J.
Aqil, U.M.H.
author_facet Sharma, Gaurav
Naushad, Mu.
Thakur, Bharti
Kumar, Amit
Negi, Poonam
Saini, Reena
Chahal, Anterpreet
Kumar, Ashok
Stadler, Florian J.
Aqil, U.M.H.
author_sort Sharma, Gaurav
collection PubMed
description Sodium dodecyl sulphate-supported iron silicophosphate (SDS/FeSP) nanocomposite was successfully fabricated by the co-precipitation method. The SDS/FeSP nanocomposite was investigated as a drug carrier for ondansetron. The cumulative drug release of ondansetron was observed at various pH values for different time intervals, i.e., from 20 min to 48 h. A ranking of the drug release was observed at different pHs; pH 2.2 > saline (pH 5.5) > pH 7.4 > pH 9.4 > distilled water. Maximum release of encapsulated drug was found to be about 45.38% at pH 2.2. The cell viability tests of SDS/FeSP nanocomposite concluded that SDS/FeSP nanocomposite was non-cytotoxic in nature.
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spelling pubmed-58769592018-04-09 Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron Sharma, Gaurav Naushad, Mu. Thakur, Bharti Kumar, Amit Negi, Poonam Saini, Reena Chahal, Anterpreet Kumar, Ashok Stadler, Florian J. Aqil, U.M.H. Int J Environ Res Public Health Article Sodium dodecyl sulphate-supported iron silicophosphate (SDS/FeSP) nanocomposite was successfully fabricated by the co-precipitation method. The SDS/FeSP nanocomposite was investigated as a drug carrier for ondansetron. The cumulative drug release of ondansetron was observed at various pH values for different time intervals, i.e., from 20 min to 48 h. A ranking of the drug release was observed at different pHs; pH 2.2 > saline (pH 5.5) > pH 7.4 > pH 9.4 > distilled water. Maximum release of encapsulated drug was found to be about 45.38% at pH 2.2. The cell viability tests of SDS/FeSP nanocomposite concluded that SDS/FeSP nanocomposite was non-cytotoxic in nature. MDPI 2018-02-27 2018-03 /pmc/articles/PMC5876959/ /pubmed/29495530 http://dx.doi.org/10.3390/ijerph15030414 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sharma, Gaurav
Naushad, Mu.
Thakur, Bharti
Kumar, Amit
Negi, Poonam
Saini, Reena
Chahal, Anterpreet
Kumar, Ashok
Stadler, Florian J.
Aqil, U.M.H.
Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron
title Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron
title_full Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron
title_fullStr Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron
title_full_unstemmed Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron
title_short Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron
title_sort sodium dodecyl sulphate-supported nanocomposite as drug carrier system for controlled delivery of ondansetron
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876959/
https://www.ncbi.nlm.nih.gov/pubmed/29495530
http://dx.doi.org/10.3390/ijerph15030414
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