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Maternal Residential Proximity to Major Roadways and Pediatric Embryonal Tumors in Offspring

The environmental determinants of pediatric embryonal tumors remain unclear. Because of the growing concern over the impact of exposures to traffic-related air pollution on pediatric cancer, we conducted a population-based study evaluating the impact of maternal residential proximity to major roadwa...

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Autores principales: Kumar, Shwetha V., Lupo, Philip J., Pompeii, Lisa A., Danysh, Heather E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877050/
https://www.ncbi.nlm.nih.gov/pubmed/29533992
http://dx.doi.org/10.3390/ijerph15030505
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author Kumar, Shwetha V.
Lupo, Philip J.
Pompeii, Lisa A.
Danysh, Heather E.
author_facet Kumar, Shwetha V.
Lupo, Philip J.
Pompeii, Lisa A.
Danysh, Heather E.
author_sort Kumar, Shwetha V.
collection PubMed
description The environmental determinants of pediatric embryonal tumors remain unclear. Because of the growing concern over the impact of exposures to traffic-related air pollution on pediatric cancer, we conducted a population-based study evaluating the impact of maternal residential proximity to major roadways on the risk of pediatric embryonal tumors in offspring. We identified children diagnosed with neuroblastoma, Wilms tumor, retinoblastoma, or hepatoblastoma at <5 years of age from the Texas Cancer Registry and selected unaffected controls from birth certificates. Two residential proximity measures were used: (1) distance to the nearest major roadway, and (2) within 500 m of a major roadway. Logistic regression was used to estimate the adjusted odds ratio (aOR) and 95% confidence interval (CI) for each proximity measure on pediatric embryonal tumors. The odds of an embryonal tumor were increased in children born to mothers living within 500 m of a major roadway (aOR = 1.24, 95% CI: 1.00, 1.54). This was consistent for most tumor subtypes, with the strongest associations observed for unilateral retinoblastoma (aOR = 2.57, 95% CI: 1.28, 5.15, for every kilometer closer the mother lived to the nearest major roadway). These findings contribute to the growing evidence that traffic-related air pollution may increase risk for certain pediatric tumors.
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spelling pubmed-58770502018-04-09 Maternal Residential Proximity to Major Roadways and Pediatric Embryonal Tumors in Offspring Kumar, Shwetha V. Lupo, Philip J. Pompeii, Lisa A. Danysh, Heather E. Int J Environ Res Public Health Article The environmental determinants of pediatric embryonal tumors remain unclear. Because of the growing concern over the impact of exposures to traffic-related air pollution on pediatric cancer, we conducted a population-based study evaluating the impact of maternal residential proximity to major roadways on the risk of pediatric embryonal tumors in offspring. We identified children diagnosed with neuroblastoma, Wilms tumor, retinoblastoma, or hepatoblastoma at <5 years of age from the Texas Cancer Registry and selected unaffected controls from birth certificates. Two residential proximity measures were used: (1) distance to the nearest major roadway, and (2) within 500 m of a major roadway. Logistic regression was used to estimate the adjusted odds ratio (aOR) and 95% confidence interval (CI) for each proximity measure on pediatric embryonal tumors. The odds of an embryonal tumor were increased in children born to mothers living within 500 m of a major roadway (aOR = 1.24, 95% CI: 1.00, 1.54). This was consistent for most tumor subtypes, with the strongest associations observed for unilateral retinoblastoma (aOR = 2.57, 95% CI: 1.28, 5.15, for every kilometer closer the mother lived to the nearest major roadway). These findings contribute to the growing evidence that traffic-related air pollution may increase risk for certain pediatric tumors. MDPI 2018-03-13 2018-03 /pmc/articles/PMC5877050/ /pubmed/29533992 http://dx.doi.org/10.3390/ijerph15030505 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kumar, Shwetha V.
Lupo, Philip J.
Pompeii, Lisa A.
Danysh, Heather E.
Maternal Residential Proximity to Major Roadways and Pediatric Embryonal Tumors in Offspring
title Maternal Residential Proximity to Major Roadways and Pediatric Embryonal Tumors in Offspring
title_full Maternal Residential Proximity to Major Roadways and Pediatric Embryonal Tumors in Offspring
title_fullStr Maternal Residential Proximity to Major Roadways and Pediatric Embryonal Tumors in Offspring
title_full_unstemmed Maternal Residential Proximity to Major Roadways and Pediatric Embryonal Tumors in Offspring
title_short Maternal Residential Proximity to Major Roadways and Pediatric Embryonal Tumors in Offspring
title_sort maternal residential proximity to major roadways and pediatric embryonal tumors in offspring
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877050/
https://www.ncbi.nlm.nih.gov/pubmed/29533992
http://dx.doi.org/10.3390/ijerph15030505
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