Cargando…

The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study

BACKGROUND: Renal biopsies performed in diabetic patients are increasing and becoming more complex. Comprehensive data on modern spectrum of biopsy-proven renal disease in Chinese diabetic patients are lacking. METHODS: In a nationwide renal biopsy survey including 71,151 native biopsies from 2004 t...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Diankun, Huang, Ting, Chen, Nan, Xu, Gang, Zhang, Ping, Luo, Yang, Wang, Yongping, Lu, Tao, Wang, Long, Xiong, Mengqi, Geng, Jian, Nie, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877445/
https://www.ncbi.nlm.nih.gov/pubmed/29607256
http://dx.doi.org/10.7717/peerj.4522
_version_ 1783310699595825152
author Liu, Diankun
Huang, Ting
Chen, Nan
Xu, Gang
Zhang, Ping
Luo, Yang
Wang, Yongping
Lu, Tao
Wang, Long
Xiong, Mengqi
Geng, Jian
Nie, Sheng
author_facet Liu, Diankun
Huang, Ting
Chen, Nan
Xu, Gang
Zhang, Ping
Luo, Yang
Wang, Yongping
Lu, Tao
Wang, Long
Xiong, Mengqi
Geng, Jian
Nie, Sheng
author_sort Liu, Diankun
collection PubMed
description BACKGROUND: Renal biopsies performed in diabetic patients are increasing and becoming more complex. Comprehensive data on modern spectrum of biopsy-proven renal disease in Chinese diabetic patients are lacking. METHODS: In a nationwide renal biopsy survey including 71,151 native biopsies from 2004 to 2014, diabetic patients were identified according to the clinical diagnosis from referral records. The clinical data were extracted from referral records and pathological reports. RESULTS: A total of 1,604 diabetic patients, including 61 patients with T1DM, were analyzed in this study. The median age is 51.39 ± 11.37 years. Male patients accounted for 58% of the population. We found that only 44.7% of diabetic patients had the isolated pathological diagnosis of diabetic nephropathy (DN), while 49.1% had non-diabetic renal disease (NDRD) alone, and 6.2% had NDRD superimposed on DN. Nephrotic syndrome (n = 824, 51.4%) was the most common clinical indication for renal biopsy. Among 887 patients with NDRD, membranous nephropathy (n = 357) was the leading diagnosis, followed by IgA nephropathy (n = 179). Hypertensive renal disease (n = 32), tubulointerstitial nephropathy (n = 27) and acute tubular necrosis (n = 16) accounted for 3.5%, 2.9%, 1.7% of the NDRD cases respectively. Nearly a half (49.2%) of patients with T1DM had NDRD. DISCUSSION: Over 55% diabetic patients with kidney disease were diagnosed as non-diabetic renal disease, among which MN and IgAN were the most common two pathological types.
format Online
Article
Text
id pubmed-5877445
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher PeerJ Inc.
record_format MEDLINE/PubMed
spelling pubmed-58774452018-03-30 The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study Liu, Diankun Huang, Ting Chen, Nan Xu, Gang Zhang, Ping Luo, Yang Wang, Yongping Lu, Tao Wang, Long Xiong, Mengqi Geng, Jian Nie, Sheng PeerJ Diabetes and Endocrinology BACKGROUND: Renal biopsies performed in diabetic patients are increasing and becoming more complex. Comprehensive data on modern spectrum of biopsy-proven renal disease in Chinese diabetic patients are lacking. METHODS: In a nationwide renal biopsy survey including 71,151 native biopsies from 2004 to 2014, diabetic patients were identified according to the clinical diagnosis from referral records. The clinical data were extracted from referral records and pathological reports. RESULTS: A total of 1,604 diabetic patients, including 61 patients with T1DM, were analyzed in this study. The median age is 51.39 ± 11.37 years. Male patients accounted for 58% of the population. We found that only 44.7% of diabetic patients had the isolated pathological diagnosis of diabetic nephropathy (DN), while 49.1% had non-diabetic renal disease (NDRD) alone, and 6.2% had NDRD superimposed on DN. Nephrotic syndrome (n = 824, 51.4%) was the most common clinical indication for renal biopsy. Among 887 patients with NDRD, membranous nephropathy (n = 357) was the leading diagnosis, followed by IgA nephropathy (n = 179). Hypertensive renal disease (n = 32), tubulointerstitial nephropathy (n = 27) and acute tubular necrosis (n = 16) accounted for 3.5%, 2.9%, 1.7% of the NDRD cases respectively. Nearly a half (49.2%) of patients with T1DM had NDRD. DISCUSSION: Over 55% diabetic patients with kidney disease were diagnosed as non-diabetic renal disease, among which MN and IgAN were the most common two pathological types. PeerJ Inc. 2018-03-27 /pmc/articles/PMC5877445/ /pubmed/29607256 http://dx.doi.org/10.7717/peerj.4522 Text en ©2018 Liu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Diabetes and Endocrinology
Liu, Diankun
Huang, Ting
Chen, Nan
Xu, Gang
Zhang, Ping
Luo, Yang
Wang, Yongping
Lu, Tao
Wang, Long
Xiong, Mengqi
Geng, Jian
Nie, Sheng
The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study
title The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study
title_full The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study
title_fullStr The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study
title_full_unstemmed The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study
title_short The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study
title_sort modern spectrum of biopsy-proven renal disease in chinese diabetic patients—a retrospective descriptive study
topic Diabetes and Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877445/
https://www.ncbi.nlm.nih.gov/pubmed/29607256
http://dx.doi.org/10.7717/peerj.4522
work_keys_str_mv AT liudiankun themodernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT huangting themodernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT chennan themodernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT xugang themodernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT zhangping themodernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT luoyang themodernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT wangyongping themodernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT lutao themodernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT wanglong themodernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT xiongmengqi themodernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT gengjian themodernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT niesheng themodernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT liudiankun modernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT huangting modernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT chennan modernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT xugang modernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT zhangping modernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT luoyang modernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT wangyongping modernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT lutao modernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT wanglong modernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT xiongmengqi modernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT gengjian modernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy
AT niesheng modernspectrumofbiopsyprovenrenaldiseaseinchinesediabeticpatientsaretrospectivedescriptivestudy