Seihai-to (TJ-90)-Induced Activation of Airway Ciliary Beatings of Mice: Ca(2+) Modulation of cAMP-Stimulated Ciliary Beatings via PDE1

Sei-hai-to (TJ-90, Qing Fei Tang), a Chinese traditional medicine, increases ciliary beat frequency (CBF) and ciliary bend angle (CBA) mediated via cAMP (3′,5′-cyclic adenosine monophosphate) accumulation modulated by Ca(2+)-activated phosphodiesterase 1 (PDE1A). A high concentration of TJ-90 (≥40 μ...

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Detalles Bibliográficos
Autores principales: Kogiso, Haruka, Ikeuchi, Yukiko, Sumiya, Masako, Hosogi, Shigekuni, Tanaka, Saori, Shimamoto, Chikao, Inui, Toshio, Marunaka, Yoshinori, Nakahari, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877519/
https://www.ncbi.nlm.nih.gov/pubmed/29495403
http://dx.doi.org/10.3390/ijms19030658

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