Cargando…

Phenotyping of Chronic Obstructive Pulmonary Disease Based on the Integration of Metabolomes and Clinical Characteristics

Apart from the refined management-oriented clinical stratification of chronic obstructive pulmonary disease (COPD), the molecular pathologies behind this highly prevalent disease have remained obscure. The aim of this study was the characterization of patients with COPD, based on the metabolomic pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kilk, Kalle, Aug, Argo, Ottas, Aigar, Soomets, Ursel, Altraja, Siiri, Altraja, Alan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877527/ https://www.ncbi.nlm.nih.gov/pubmed/29495451 http://dx.doi.org/10.3390/ijms19030666

Ejemplares similares

E-Cigarette Affects the Metabolome of Primary Normal Human Bronchial Epithelial Cells
por: Aug, Argo, et al.
Publicado: (2015)

The effect of obstructive sleep apnea on peripheral blood amino acid and biogenic amine metabolome at multiple time points overnight
por: Kiens, Ott, et al.
Publicado: (2021)

Apnoea–hypopnoea index of 5 events·h(−1) as a metabolomic threshold in patients with sleep complaints
por: Kiens, Ott, et al.
Publicado: (2023)

Increased DNA Damage in Progression Of COPD: A Response By Poly(ADP-Ribose) Polymerase-1
por: Oit-Wiscombe, Ingrid, et al.
Publicado: (2013)

Metabolomic Profile of Abdominal Aortic Aneurysm
por: Lieberg, Jüri, et al.
Publicado: (2021)

Metabolomic Differences between the Skin and Blood Sera of Atopic Dermatitis and Psoriasis
por: Ilves, Liis, et al.
Publicado: (2022)

The metabolic analysis of psoriasis identifies the associated metabolites while providing computational models for the monitoring of the disease
por: Ottas, Aigar, et al.
Publicado: (2017)

Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation
por: Ottas, Aigar, et al.
Publicado: (2017)

Metabolomic Analysis of Skin Biopsies from Patients with Atopic Dermatitis Reveals Hallmarks of Inflammation, Disrupted Barrier Function and Oxidative Stress
por: ILVES, Liis, et al.
Publicado: (2021)

Hyperproliferation is the main driver of metabolomic changes in psoriasis lesional skin
por: Pohla, Liis, et al.
Publicado: (2020)

Synthesis of tenascin and laminin beta2 chain in human bronchial epithelial cells is enhanced by cysteinyl leukotrienes via CysLT(1 )receptor
por: Altraja, Siiri, et al.
Publicado: (2008)

Diverse Effects of Glutathione and UPF Peptides on Antioxidant Defense System in Human Erythroleukemia Cells K562
por: Kairane, Ceslava, et al.
Publicado: (2012)

Small Cell Lung Cancer Patient with Profound Hyponatremia and Acute Neurological Symptoms: An Effective Treatment with Fludrocortisone
por: Jaal, Jana, et al.
Publicado: (2015)

Organisation of diagnosis and treatment of idiopathic pulmonary fibrosis and other interstitial lung diseases in the Nordic countries
por: Bendstrup, Elisabeth, et al.
Publicado: (2015)

Rapid tests reduce the burden of tuberculosis in Azerbaijan prisons: special emphasis on rifampicin-resistance
por: Gurbanova, E, et al.
Publicado: (2018)

Whole exome sequencing of benign pulmonary metastasizing leiomyoma reveals mutation in the BMP8B gene
por: Sõritsa, Deniss, et al.
Publicado: (2018)

Taurine and Epidermal Growth Factor Belong to the Signature of First-Episode Psychosis
por: Koido, Kati, et al.
Publicado: (2016)

International multidisciplinary team discussions on the diagnosis of idiopathic non-specific interstitial pneumonia and the development of connective tissue disease
por: Møller, Janne, et al.
Publicado: (2021)

Changes in Lipoprotein Particles in the Blood Serum of Patients with Lichen Planus
por: Ilves, Liis, et al.
Publicado: (2023)

Mapping Metabolite and ICD-10 Associations
por: Taalberg, Egon, et al.
Publicado: (2020)

Effects of RIPC on the Metabolome in Patients Undergoing Vascular Surgery: A Randomized Controlled Trial
por: Eerik, Kadri, et al.
Publicado: (2022)

Plasma Metabolomic Signatures of Chronic Obstructive Pulmonary Disease and the Impact of Genetic Variants on Phenotype-Driven Modules
por: Gillenwater, Lucas A., et al.
Publicado: (2020)

Effects of RIPC on the Metabolomical Profile during Lower Limb Digital Subtraction Angiography: A Randomized Controlled Trial
por: Kuusik, Karl, et al.
Publicado: (2023)

The characteristics of the frequent exacerbators with chronic bronchitis phenotype and the asthma-chronic obstructive pulmonary disease overlap syndrome phenotype in chronic obstructive pulmonary disease patients: A meta-analysis and system review
por: Wu, Jian-Jun, et al.
Publicado: (2019)

Chronic obstructive pulmonary disease subpopulations and phenotyping
por: Segal, Leopoldo N., et al.
Publicado: (2018)

Metabolic profile associated with distinct behavioral coping strategies of 129Sv and Bl6 mice in repeated motility test
por: Narvik, Jane, et al.
Publicado: (2018)

Reduced expression of miR-146a in human bronchial epithelial cells alters neutrophil migration
por: Kivihall, Anet, et al.
Publicado: (2019)

Characteristics of inflammatory phenotypes in patients with chronic obstructive pulmonary disease: a cross-sectional study
por: Wen, Xiang, et al.
Publicado: (2023)

An Updated Overview of Metabolomic Profile Changes in Chronic Obstructive Pulmonary Disease
por: Ran, Nan, et al.
Publicado: (2019)

Changes in targeted metabolomics in lung tissue of chronic obstructive pulmonary disease
por: Feng, Yi, et al.
Publicado: (2023)

Chronic obstructive pulmonary disease phenotypes and balance impairment
por: Voica, Alina Sorina, et al.
Publicado: (2016)

Metabolomics of chronic obstructive pulmonary disease and obstructive sleep apnea syndrome: response to Maniscalco and Motta
por: Mlynarz, P., et al.
Publicado: (2016)

Repeated Administration of D-Amphetamine Induces Distinct Alterations in Behavior and Metabolite Levels in 129Sv and Bl6 Mouse Strains
por: Vanaveski, Taavi, et al.
Publicado: (2018)

Chronic cough as a novel phenotype of chronic obstructive pulmonary disease
por: Koo, Hyeon-Kyoung, et al.
Publicado: (2018)

Integration of metabolomics and network pharmacology to reveal the protective mechanism underlying Qibai Pingfei capsule on chronic obstructive pulmonary disease
por: Xie, Jinghui, et al.
Publicado: (2023)

Metabolomic changes in patients with chronic obstructive pulmonary disease with abnormal Savda syndrome
por: XU, WEI-FANG, et al.
Publicado: (2015)

Safety of prolonged treatment with bedaquiline in programmatic conditions
por: Zhurkin, Dzmitriy, et al.
Publicado: (2022)

Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome
por: Rhee, Chin Kook
Publicado: (2015)

Annotating and detecting phenotypic information for chronic obstructive pulmonary disease
por: Ju, Meizhi, et al.
Publicado: (2019)

Phenotyping Cardiopulmonary Exercise Limitations in Chronic Obstructive Pulmonary Disease
por: Gelinas, Jinelle, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_co4ij41bhotpv7viu9ia1df955