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Anti-Hypertensive Effects of Acacia Polyphenol in Spontaneously Hypertensive Rats

We have previously demonstrated that acacia polyphenol (AP) exerts strong anti-obesity, anti-diabetic, and anti-atopic dermatitis effects. In the present study, we investigated the anti-hypertensive effects of AP. Spontaneously hypertensive rats (SHR) with hypertension and control Wistar Kyoto rats...

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Autores principales: Ikarashi, Nobutomo, Toda, Takahiro, Hatakeyama, Yusuke, Kusunoki, Yoshiki, Kon, Risako, Mizukami, Nanaho, Kaneko, Miho, Ogawa, Sosuke, Sugiyama, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877561/
https://www.ncbi.nlm.nih.gov/pubmed/29494506
http://dx.doi.org/10.3390/ijms19030700
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author Ikarashi, Nobutomo
Toda, Takahiro
Hatakeyama, Yusuke
Kusunoki, Yoshiki
Kon, Risako
Mizukami, Nanaho
Kaneko, Miho
Ogawa, Sosuke
Sugiyama, Kiyoshi
author_facet Ikarashi, Nobutomo
Toda, Takahiro
Hatakeyama, Yusuke
Kusunoki, Yoshiki
Kon, Risako
Mizukami, Nanaho
Kaneko, Miho
Ogawa, Sosuke
Sugiyama, Kiyoshi
author_sort Ikarashi, Nobutomo
collection PubMed
description We have previously demonstrated that acacia polyphenol (AP) exerts strong anti-obesity, anti-diabetic, and anti-atopic dermatitis effects. In the present study, we investigated the anti-hypertensive effects of AP. Spontaneously hypertensive rats (SHR) with hypertension and control Wistar Kyoto rats (WKY) were used. WKY and SHR were fed AP-containing food or AP-free food (control group) ad libitum for 4 weeks, and their blood pressures were measured. After AP administration, both systolic and diastolic blood pressures were significantly lower in the SHR group than in the control group. There were no differences in the systolic or diastolic blood pressure of WKY between the AP group and the control group. Angiotensin-converting enzyme (ACE) activity, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expression, and superoxide dismutase (SOD) activity in SHR kidneys were not altered by AP administration. Blood SOD activity in SHR was significantly higher in the AP group than in the control group. AP exerts anti-hypertensive effects on hypertension but has almost no effect on normal blood pressure. The anti-hypertensive effects of AP may be related to the anti-oxidative effects of increased blood SOD activity.
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spelling pubmed-58775612018-04-09 Anti-Hypertensive Effects of Acacia Polyphenol in Spontaneously Hypertensive Rats Ikarashi, Nobutomo Toda, Takahiro Hatakeyama, Yusuke Kusunoki, Yoshiki Kon, Risako Mizukami, Nanaho Kaneko, Miho Ogawa, Sosuke Sugiyama, Kiyoshi Int J Mol Sci Article We have previously demonstrated that acacia polyphenol (AP) exerts strong anti-obesity, anti-diabetic, and anti-atopic dermatitis effects. In the present study, we investigated the anti-hypertensive effects of AP. Spontaneously hypertensive rats (SHR) with hypertension and control Wistar Kyoto rats (WKY) were used. WKY and SHR were fed AP-containing food or AP-free food (control group) ad libitum for 4 weeks, and their blood pressures were measured. After AP administration, both systolic and diastolic blood pressures were significantly lower in the SHR group than in the control group. There were no differences in the systolic or diastolic blood pressure of WKY between the AP group and the control group. Angiotensin-converting enzyme (ACE) activity, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expression, and superoxide dismutase (SOD) activity in SHR kidneys were not altered by AP administration. Blood SOD activity in SHR was significantly higher in the AP group than in the control group. AP exerts anti-hypertensive effects on hypertension but has almost no effect on normal blood pressure. The anti-hypertensive effects of AP may be related to the anti-oxidative effects of increased blood SOD activity. MDPI 2018-03-01 /pmc/articles/PMC5877561/ /pubmed/29494506 http://dx.doi.org/10.3390/ijms19030700 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ikarashi, Nobutomo
Toda, Takahiro
Hatakeyama, Yusuke
Kusunoki, Yoshiki
Kon, Risako
Mizukami, Nanaho
Kaneko, Miho
Ogawa, Sosuke
Sugiyama, Kiyoshi
Anti-Hypertensive Effects of Acacia Polyphenol in Spontaneously Hypertensive Rats
title Anti-Hypertensive Effects of Acacia Polyphenol in Spontaneously Hypertensive Rats
title_full Anti-Hypertensive Effects of Acacia Polyphenol in Spontaneously Hypertensive Rats
title_fullStr Anti-Hypertensive Effects of Acacia Polyphenol in Spontaneously Hypertensive Rats
title_full_unstemmed Anti-Hypertensive Effects of Acacia Polyphenol in Spontaneously Hypertensive Rats
title_short Anti-Hypertensive Effects of Acacia Polyphenol in Spontaneously Hypertensive Rats
title_sort anti-hypertensive effects of acacia polyphenol in spontaneously hypertensive rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877561/
https://www.ncbi.nlm.nih.gov/pubmed/29494506
http://dx.doi.org/10.3390/ijms19030700
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