Cargando…

Influence of Single-Nucleotide Polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the Changes in Anthropometric Indices and Blood Measurements through Exercise-Centered Lifestyle Intervention in Japanese Middle-Aged Men

The purpose of the current study was to examine the influence of single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor-δ (PPAR-δ), PPAR-γ, and α2 isoforms of the catalytic subunit of AMP-activated protein kinase (PRKAA2) on the extent of changes in anthropometric i...

Descripción completa

Detalles Bibliográficos
Autores principales: Nishida, Yuichiro, Iyadomi, Minako, Tominaga, Hirotaka, Taniguchi, Hiroaki, Higaki, Yasuki, Tanaka, Hiroaki, Horita, Mikako, Shimanoe, Chisato, Hara, Megumi, Tanaka, Keitaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877564/
https://www.ncbi.nlm.nih.gov/pubmed/29494521
http://dx.doi.org/10.3390/ijms19030703
_version_ 1783310720398524416
author Nishida, Yuichiro
Iyadomi, Minako
Tominaga, Hirotaka
Taniguchi, Hiroaki
Higaki, Yasuki
Tanaka, Hiroaki
Horita, Mikako
Shimanoe, Chisato
Hara, Megumi
Tanaka, Keitaro
author_facet Nishida, Yuichiro
Iyadomi, Minako
Tominaga, Hirotaka
Taniguchi, Hiroaki
Higaki, Yasuki
Tanaka, Hiroaki
Horita, Mikako
Shimanoe, Chisato
Hara, Megumi
Tanaka, Keitaro
author_sort Nishida, Yuichiro
collection PubMed
description The purpose of the current study was to examine the influence of single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor-δ (PPAR-δ), PPAR-γ, and α2 isoforms of the catalytic subunit of AMP-activated protein kinase (PRKAA2) on the extent of changes in anthropometric indices and blood measurements through exercise-centered lifestyle intervention in middle-aged men. A total of 109 Japanese middle-aged male subjects (47.0 ± 0.4 years) participated in the baseline health checkup, 6-month exercise-centered lifestyle intervention, and second checkup conducted several months after the subject completed the intervention. The body mass index (BMI), waist circumference, and clinical measurements, including hemoglobin A(lc) (HbA(1c)), triglyceride (TG), alanine aminotransferase (ALT), and γ-glutamyl-transpeptidase (γ-GTP), were measured at the baseline and second checkup. The three SNPs of PPAR-δ A/G (rs2267668), PPAR-γ C/G (rs1801282), and PRKAA2 A/G (rs1418442) were determined. Blunted responses in the reduction in the BMI and waist circumference were observed in A/A carriers of PPAR-δ SNP compared with G allele carriers (all p < 0.05). The A/A carriers also displayed less-marked improvements in HbA(1c), TG, ALT, and γ-GTP (all p < 0.05). The current results suggest that A/A carriers of PPAR-δ SNP (rs2267668) may enjoy fewer beneficial effects of exercise-centered lifestyle intervention on anthropometric indices and blood measurements.
format Online
Article
Text
id pubmed-5877564
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-58775642018-04-09 Influence of Single-Nucleotide Polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the Changes in Anthropometric Indices and Blood Measurements through Exercise-Centered Lifestyle Intervention in Japanese Middle-Aged Men Nishida, Yuichiro Iyadomi, Minako Tominaga, Hirotaka Taniguchi, Hiroaki Higaki, Yasuki Tanaka, Hiroaki Horita, Mikako Shimanoe, Chisato Hara, Megumi Tanaka, Keitaro Int J Mol Sci Article The purpose of the current study was to examine the influence of single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor-δ (PPAR-δ), PPAR-γ, and α2 isoforms of the catalytic subunit of AMP-activated protein kinase (PRKAA2) on the extent of changes in anthropometric indices and blood measurements through exercise-centered lifestyle intervention in middle-aged men. A total of 109 Japanese middle-aged male subjects (47.0 ± 0.4 years) participated in the baseline health checkup, 6-month exercise-centered lifestyle intervention, and second checkup conducted several months after the subject completed the intervention. The body mass index (BMI), waist circumference, and clinical measurements, including hemoglobin A(lc) (HbA(1c)), triglyceride (TG), alanine aminotransferase (ALT), and γ-glutamyl-transpeptidase (γ-GTP), were measured at the baseline and second checkup. The three SNPs of PPAR-δ A/G (rs2267668), PPAR-γ C/G (rs1801282), and PRKAA2 A/G (rs1418442) were determined. Blunted responses in the reduction in the BMI and waist circumference were observed in A/A carriers of PPAR-δ SNP compared with G allele carriers (all p < 0.05). The A/A carriers also displayed less-marked improvements in HbA(1c), TG, ALT, and γ-GTP (all p < 0.05). The current results suggest that A/A carriers of PPAR-δ SNP (rs2267668) may enjoy fewer beneficial effects of exercise-centered lifestyle intervention on anthropometric indices and blood measurements. MDPI 2018-03-01 /pmc/articles/PMC5877564/ /pubmed/29494521 http://dx.doi.org/10.3390/ijms19030703 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nishida, Yuichiro
Iyadomi, Minako
Tominaga, Hirotaka
Taniguchi, Hiroaki
Higaki, Yasuki
Tanaka, Hiroaki
Horita, Mikako
Shimanoe, Chisato
Hara, Megumi
Tanaka, Keitaro
Influence of Single-Nucleotide Polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the Changes in Anthropometric Indices and Blood Measurements through Exercise-Centered Lifestyle Intervention in Japanese Middle-Aged Men
title Influence of Single-Nucleotide Polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the Changes in Anthropometric Indices and Blood Measurements through Exercise-Centered Lifestyle Intervention in Japanese Middle-Aged Men
title_full Influence of Single-Nucleotide Polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the Changes in Anthropometric Indices and Blood Measurements through Exercise-Centered Lifestyle Intervention in Japanese Middle-Aged Men
title_fullStr Influence of Single-Nucleotide Polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the Changes in Anthropometric Indices and Blood Measurements through Exercise-Centered Lifestyle Intervention in Japanese Middle-Aged Men
title_full_unstemmed Influence of Single-Nucleotide Polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the Changes in Anthropometric Indices and Blood Measurements through Exercise-Centered Lifestyle Intervention in Japanese Middle-Aged Men
title_short Influence of Single-Nucleotide Polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the Changes in Anthropometric Indices and Blood Measurements through Exercise-Centered Lifestyle Intervention in Japanese Middle-Aged Men
title_sort influence of single-nucleotide polymorphisms in ppar-δ, ppar-γ, and prkaa2 on the changes in anthropometric indices and blood measurements through exercise-centered lifestyle intervention in japanese middle-aged men
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877564/
https://www.ncbi.nlm.nih.gov/pubmed/29494521
http://dx.doi.org/10.3390/ijms19030703
work_keys_str_mv AT nishidayuichiro influenceofsinglenucleotidepolymorphismsinppardppargandprkaa2onthechangesinanthropometricindicesandbloodmeasurementsthroughexercisecenteredlifestyleinterventioninjapanesemiddleagedmen
AT iyadomiminako influenceofsinglenucleotidepolymorphismsinppardppargandprkaa2onthechangesinanthropometricindicesandbloodmeasurementsthroughexercisecenteredlifestyleinterventioninjapanesemiddleagedmen
AT tominagahirotaka influenceofsinglenucleotidepolymorphismsinppardppargandprkaa2onthechangesinanthropometricindicesandbloodmeasurementsthroughexercisecenteredlifestyleinterventioninjapanesemiddleagedmen
AT taniguchihiroaki influenceofsinglenucleotidepolymorphismsinppardppargandprkaa2onthechangesinanthropometricindicesandbloodmeasurementsthroughexercisecenteredlifestyleinterventioninjapanesemiddleagedmen
AT higakiyasuki influenceofsinglenucleotidepolymorphismsinppardppargandprkaa2onthechangesinanthropometricindicesandbloodmeasurementsthroughexercisecenteredlifestyleinterventioninjapanesemiddleagedmen
AT tanakahiroaki influenceofsinglenucleotidepolymorphismsinppardppargandprkaa2onthechangesinanthropometricindicesandbloodmeasurementsthroughexercisecenteredlifestyleinterventioninjapanesemiddleagedmen
AT horitamikako influenceofsinglenucleotidepolymorphismsinppardppargandprkaa2onthechangesinanthropometricindicesandbloodmeasurementsthroughexercisecenteredlifestyleinterventioninjapanesemiddleagedmen
AT shimanoechisato influenceofsinglenucleotidepolymorphismsinppardppargandprkaa2onthechangesinanthropometricindicesandbloodmeasurementsthroughexercisecenteredlifestyleinterventioninjapanesemiddleagedmen
AT haramegumi influenceofsinglenucleotidepolymorphismsinppardppargandprkaa2onthechangesinanthropometricindicesandbloodmeasurementsthroughexercisecenteredlifestyleinterventioninjapanesemiddleagedmen
AT tanakakeitaro influenceofsinglenucleotidepolymorphismsinppardppargandprkaa2onthechangesinanthropometricindicesandbloodmeasurementsthroughexercisecenteredlifestyleinterventioninjapanesemiddleagedmen