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Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids
Hypertrophic scars and keloids are fibroproliferative disorders that may arise after any deep cutaneous injury caused by trauma, burns, surgery, etc. Hypertrophic scars and keloids are cosmetically problematic, and in combination with functional problems such as contractures and subjective symptoms...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877572/ https://www.ncbi.nlm.nih.gov/pubmed/29498630 http://dx.doi.org/10.3390/ijms19030711 |
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author | Lee, Ho Jun Jang, Yong Ju |
author_facet | Lee, Ho Jun Jang, Yong Ju |
author_sort | Lee, Ho Jun |
collection | PubMed |
description | Hypertrophic scars and keloids are fibroproliferative disorders that may arise after any deep cutaneous injury caused by trauma, burns, surgery, etc. Hypertrophic scars and keloids are cosmetically problematic, and in combination with functional problems such as contractures and subjective symptoms including pruritus, these significantly affect patients’ quality of life. There have been many studies on hypertrophic scars and keloids; but the mechanisms underlying scar formation have not yet been well established, and prophylactic and treatment strategies remain unsatisfactory. In this review, the authors introduce and summarize classical concepts surrounding wound healing and review recent understandings of the biology, prevention and treatment strategies for hypertrophic scars and keloids. |
format | Online Article Text |
id | pubmed-5877572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58775722018-04-09 Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids Lee, Ho Jun Jang, Yong Ju Int J Mol Sci Review Hypertrophic scars and keloids are fibroproliferative disorders that may arise after any deep cutaneous injury caused by trauma, burns, surgery, etc. Hypertrophic scars and keloids are cosmetically problematic, and in combination with functional problems such as contractures and subjective symptoms including pruritus, these significantly affect patients’ quality of life. There have been many studies on hypertrophic scars and keloids; but the mechanisms underlying scar formation have not yet been well established, and prophylactic and treatment strategies remain unsatisfactory. In this review, the authors introduce and summarize classical concepts surrounding wound healing and review recent understandings of the biology, prevention and treatment strategies for hypertrophic scars and keloids. MDPI 2018-03-02 /pmc/articles/PMC5877572/ /pubmed/29498630 http://dx.doi.org/10.3390/ijms19030711 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lee, Ho Jun Jang, Yong Ju Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids |
title | Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids |
title_full | Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids |
title_fullStr | Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids |
title_full_unstemmed | Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids |
title_short | Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids |
title_sort | recent understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877572/ https://www.ncbi.nlm.nih.gov/pubmed/29498630 http://dx.doi.org/10.3390/ijms19030711 |
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