cGMP Signaling in the Cardiovascular System—The Role of Compartmentation and Its Live Cell Imaging

The ubiquitous second messenger 3′,5′-cyclic guanosine monophosphate (cGMP) regulates multiple physiologic processes in the cardiovascular system. Its intracellular effects are mediated by stringently controlled subcellular microdomains. In this review, we will illustrate the current techniques avai...

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Detalles Bibliográficos
Autores principales: Bork, Nadja I., Nikolaev, Viacheslav O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877662/
https://www.ncbi.nlm.nih.gov/pubmed/29534460
http://dx.doi.org/10.3390/ijms19030801
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author Bork, Nadja I.
Nikolaev, Viacheslav O.
author_facet Bork, Nadja I.
Nikolaev, Viacheslav O.
author_sort Bork, Nadja I.
collection PubMed
description The ubiquitous second messenger 3′,5′-cyclic guanosine monophosphate (cGMP) regulates multiple physiologic processes in the cardiovascular system. Its intracellular effects are mediated by stringently controlled subcellular microdomains. In this review, we will illustrate the current techniques available for real-time cGMP measurements with a specific focus on live cell imaging methods. We will also discuss currently accepted and emerging mechanisms of cGMP compartmentation in the cardiovascular system.
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spelling pubmed-58776622018-04-09 cGMP Signaling in the Cardiovascular System—The Role of Compartmentation and Its Live Cell Imaging Bork, Nadja I. Nikolaev, Viacheslav O. Int J Mol Sci Review The ubiquitous second messenger 3′,5′-cyclic guanosine monophosphate (cGMP) regulates multiple physiologic processes in the cardiovascular system. Its intracellular effects are mediated by stringently controlled subcellular microdomains. In this review, we will illustrate the current techniques available for real-time cGMP measurements with a specific focus on live cell imaging methods. We will also discuss currently accepted and emerging mechanisms of cGMP compartmentation in the cardiovascular system. MDPI 2018-03-10 /pmc/articles/PMC5877662/ /pubmed/29534460 http://dx.doi.org/10.3390/ijms19030801 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bork, Nadja I.
Nikolaev, Viacheslav O.
cGMP Signaling in the Cardiovascular System—The Role of Compartmentation and Its Live Cell Imaging
title cGMP Signaling in the Cardiovascular System—The Role of Compartmentation and Its Live Cell Imaging
title_full cGMP Signaling in the Cardiovascular System—The Role of Compartmentation and Its Live Cell Imaging
title_fullStr cGMP Signaling in the Cardiovascular System—The Role of Compartmentation and Its Live Cell Imaging
title_full_unstemmed cGMP Signaling in the Cardiovascular System—The Role of Compartmentation and Its Live Cell Imaging
title_short cGMP Signaling in the Cardiovascular System—The Role of Compartmentation and Its Live Cell Imaging
title_sort cgmp signaling in the cardiovascular system—the role of compartmentation and its live cell imaging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877662/
https://www.ncbi.nlm.nih.gov/pubmed/29534460
http://dx.doi.org/10.3390/ijms19030801
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