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Preliminary Structure-Activity Relationship (SAR) of a Novel Series of Pyrazole SKF-96365 Analogues as Potential Store-Operated Calcium Entry (SOCE) Inhibitors

From a series of (1R, 1S)-1[β-(phenylalkoxy)-(phenetyl)]-1H-pyrazolium hydrochloride as new analogues of SKF-96365, one has an interesting effect for endoplasmic reticulum (ER) Ca(2+) release and store-operated Ca(2+) entry (SOCE) (IC(50) 25 μM) on the PLP-B lymphocyte cell line. A successful resolu...

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Detalles Bibliográficos
Autores principales:	Dago, Camille D., Maux, Paul Le, Roisnel, Thierry, Brigaudeau, Christophe, Bekro, Yves-Alain, Mignen, Olivier, Bazureau, Jean-Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877717/ https://www.ncbi.nlm.nih.gov/pubmed/29538341 http://dx.doi.org/10.3390/ijms19030856

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