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Treatment, Therapy and Management of Metabolic Epilepsy: A Systematic Review
Metabolic epilepsy is a metabolic abnormality which is associated with an increased risk of epilepsy development in affected individuals. Commonly used antiepileptic drugs are typically ineffective against metabolic epilepsy as they do not address its root cause. Presently, there is no review availa...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877732/ https://www.ncbi.nlm.nih.gov/pubmed/29543761 http://dx.doi.org/10.3390/ijms19030871 |
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author | Lin Lin Lee, Vanessa Kar Meng Choo, Brandon Chung, Yin-Sir P. Kundap, Uday Kumari, Yatinesh Shaikh, Mohd. Farooq |
author_facet | Lin Lin Lee, Vanessa Kar Meng Choo, Brandon Chung, Yin-Sir P. Kundap, Uday Kumari, Yatinesh Shaikh, Mohd. Farooq |
author_sort | Lin Lin Lee, Vanessa |
collection | PubMed |
description | Metabolic epilepsy is a metabolic abnormality which is associated with an increased risk of epilepsy development in affected individuals. Commonly used antiepileptic drugs are typically ineffective against metabolic epilepsy as they do not address its root cause. Presently, there is no review available which summarizes all the treatment options for metabolic epilepsy. Thus, we systematically reviewed literature which reported on the treatment, therapy and management of metabolic epilepsy from four databases, namely PubMed, Springer, Scopus and ScienceDirect. After applying our inclusion and exclusion criteria as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we reviewed a total of 43 articles. Based on the reviewed articles, we summarized the methods used for the treatment, therapy and management of metabolic epilepsy. These methods were tailored to address the root causes of the metabolic disturbances rather than targeting the epilepsy phenotype alone. Diet modification and dietary supplementation, alone or in combination with antiepileptic drugs, are used in tackling the different types of metabolic epilepsy. Identification, treatment, therapy and management of the underlying metabolic derangements can improve behavior, cognitive function and reduce seizure frequency and/or severity in patients. |
format | Online Article Text |
id | pubmed-5877732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58777322018-04-09 Treatment, Therapy and Management of Metabolic Epilepsy: A Systematic Review Lin Lin Lee, Vanessa Kar Meng Choo, Brandon Chung, Yin-Sir P. Kundap, Uday Kumari, Yatinesh Shaikh, Mohd. Farooq Int J Mol Sci Review Metabolic epilepsy is a metabolic abnormality which is associated with an increased risk of epilepsy development in affected individuals. Commonly used antiepileptic drugs are typically ineffective against metabolic epilepsy as they do not address its root cause. Presently, there is no review available which summarizes all the treatment options for metabolic epilepsy. Thus, we systematically reviewed literature which reported on the treatment, therapy and management of metabolic epilepsy from four databases, namely PubMed, Springer, Scopus and ScienceDirect. After applying our inclusion and exclusion criteria as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we reviewed a total of 43 articles. Based on the reviewed articles, we summarized the methods used for the treatment, therapy and management of metabolic epilepsy. These methods were tailored to address the root causes of the metabolic disturbances rather than targeting the epilepsy phenotype alone. Diet modification and dietary supplementation, alone or in combination with antiepileptic drugs, are used in tackling the different types of metabolic epilepsy. Identification, treatment, therapy and management of the underlying metabolic derangements can improve behavior, cognitive function and reduce seizure frequency and/or severity in patients. MDPI 2018-03-15 /pmc/articles/PMC5877732/ /pubmed/29543761 http://dx.doi.org/10.3390/ijms19030871 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lin Lin Lee, Vanessa Kar Meng Choo, Brandon Chung, Yin-Sir P. Kundap, Uday Kumari, Yatinesh Shaikh, Mohd. Farooq Treatment, Therapy and Management of Metabolic Epilepsy: A Systematic Review |
title | Treatment, Therapy and Management of Metabolic Epilepsy: A Systematic Review |
title_full | Treatment, Therapy and Management of Metabolic Epilepsy: A Systematic Review |
title_fullStr | Treatment, Therapy and Management of Metabolic Epilepsy: A Systematic Review |
title_full_unstemmed | Treatment, Therapy and Management of Metabolic Epilepsy: A Systematic Review |
title_short | Treatment, Therapy and Management of Metabolic Epilepsy: A Systematic Review |
title_sort | treatment, therapy and management of metabolic epilepsy: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877732/ https://www.ncbi.nlm.nih.gov/pubmed/29543761 http://dx.doi.org/10.3390/ijms19030871 |
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