Study of Imidazolium Salt Derivatives as PIK3CA Inhibitors Using a Comprehensive in Silico Method

A series of imidazolium salt derivatives have demonstrated potent antitumor activity in prior research. A comprehensive in silicon method was carried out to identify the putative protein target and detailed structure-activity relationship of the compounds. The Topomer CoMFA and CoMSIA techniques wer...

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Detalles Bibliográficos
Autores principales: Wang, Ming-yang, Liang, Jing-wei, Li, Xin-yang, Olounfeh, Kamara Mohamed, Li, Shi-long, Wang, Shan, Wang, Lin, Meng, Fan-hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877757/
https://www.ncbi.nlm.nih.gov/pubmed/29562629
http://dx.doi.org/10.3390/ijms19030896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877757/
https://www.ncbi.nlm.nih.gov/pubmed/29562629
http://dx.doi.org/10.3390/ijms19030896

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