PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders

Research in recent years on peroxisome proliferator-activated receptor (PPAR)β/δ indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. PPARβ/δ activation might help prevent the development of metabolic disorders, i...

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Detalles Bibliográficos
Autores principales: Palomer, Xavier, Barroso, Emma, Pizarro-Delgado, Javier, Peña, Lucía, Botteri, Gaia, Zarei, Mohammad, Aguilar, David, Montori-Grau, Marta, Vázquez-Carrera, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877774/
https://www.ncbi.nlm.nih.gov/pubmed/29558390
http://dx.doi.org/10.3390/ijms19030913
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author Palomer, Xavier
Barroso, Emma
Pizarro-Delgado, Javier
Peña, Lucía
Botteri, Gaia
Zarei, Mohammad
Aguilar, David
Montori-Grau, Marta
Vázquez-Carrera, Manuel
author_facet Palomer, Xavier
Barroso, Emma
Pizarro-Delgado, Javier
Peña, Lucía
Botteri, Gaia
Zarei, Mohammad
Aguilar, David
Montori-Grau, Marta
Vázquez-Carrera, Manuel
author_sort Palomer, Xavier
collection PubMed
description Research in recent years on peroxisome proliferator-activated receptor (PPAR)β/δ indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. PPARβ/δ activation might help prevent the development of metabolic disorders, including obesity, dyslipidaemia, type 2 diabetes mellitus and non-alcoholic fatty liver disease. This review highlights research findings on the PPARβ/δ regulation of energy metabolism and the development of diseases related to altered cellular and body metabolism. It also describes the potential of the pharmacological activation of PPARβ/δ as a treatment for human metabolic disorders.
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spelling pubmed-58777742018-04-09 PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders Palomer, Xavier Barroso, Emma Pizarro-Delgado, Javier Peña, Lucía Botteri, Gaia Zarei, Mohammad Aguilar, David Montori-Grau, Marta Vázquez-Carrera, Manuel Int J Mol Sci Review Research in recent years on peroxisome proliferator-activated receptor (PPAR)β/δ indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. PPARβ/δ activation might help prevent the development of metabolic disorders, including obesity, dyslipidaemia, type 2 diabetes mellitus and non-alcoholic fatty liver disease. This review highlights research findings on the PPARβ/δ regulation of energy metabolism and the development of diseases related to altered cellular and body metabolism. It also describes the potential of the pharmacological activation of PPARβ/δ as a treatment for human metabolic disorders. MDPI 2018-03-20 /pmc/articles/PMC5877774/ /pubmed/29558390 http://dx.doi.org/10.3390/ijms19030913 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Palomer, Xavier
Barroso, Emma
Pizarro-Delgado, Javier
Peña, Lucía
Botteri, Gaia
Zarei, Mohammad
Aguilar, David
Montori-Grau, Marta
Vázquez-Carrera, Manuel
PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders
title PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders
title_full PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders
title_fullStr PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders
title_full_unstemmed PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders
title_short PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders
title_sort pparβ/δ: a key therapeutic target in metabolic disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877774/
https://www.ncbi.nlm.nih.gov/pubmed/29558390
http://dx.doi.org/10.3390/ijms19030913
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