Site-Mutation of Hydrophobic Core Residues Synchronically Poise Super Interleukin 2 for Signaling: Identifying Distant Structural Effects through Affordable Computations

A superkine variant of interleukin-2 with six site mutations away from the binding interface developed from the yeast display technique has been previously characterized as undergoing a distal structure alteration which is responsible for its super-potency and provides an elegant case study with whi...

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Detalles Bibliográficos
Autores principales: Mei, Longcan, Zhou, Yanping, Zhu, Lizhe, Liu, Changlin, Wu, Zhuo, Wang, Fangkui, Hao, Gefei, Yu, Di, Yuan, Hong, Cui, Yanfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877777/
https://www.ncbi.nlm.nih.gov/pubmed/29558421
http://dx.doi.org/10.3390/ijms19030916

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