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Response‐adaptive designs for binary responses: How to offer patient benefit while being robust to time trends?
Response‐adaptive randomisation (RAR) can considerably improve the chances of a successful treatment outcome for patients in a clinical trial by skewing the allocation probability towards better performing treatments as data accumulates. There is considerable interest in using RAR designs in drug de...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877788/ https://www.ncbi.nlm.nih.gov/pubmed/29266692 http://dx.doi.org/10.1002/pst.1845 |