Widespread domain-like perturbations of DNA methylation in whole blood of Down syndrome neonates

INTRODUCTION: Down syndrome (DS) is the most frequent genetic cause of intellectual disability. Despite the fact that more than 50 years have passed since the discovery of its genetic aberrations, the exact pathogenesis of the DS phenotype has remained largely unexplained. It was recently hypothesiz...

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Detalles Bibliográficos
Autores principales: Henneman, Peter, Bouman, Arjan, Mul, Adri, Knegt, Lia, van der Kevie-Kersemaekers, Anne-Marie, Zwaveling-Soonawala, Nitash, Meijers-Heijboer, Hanne E. J., van Trotsenburg, A. S. Paul, Mannens, Marcel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877863/
https://www.ncbi.nlm.nih.gov/pubmed/29601581
http://dx.doi.org/10.1371/journal.pone.0194938

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