Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice

Advanced age is not only a major risk factor for a range of disorders within an aging individual but may also enhance susceptibility for disease in the next generation. In humans, advanced paternal age has been associated with increased risk for a number of diseases. Experiments in rodent models hav...

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Detalles Bibliográficos
Autores principales: Xie, Kan, Ryan, Devon P., Pearson, Brandon L., Henzel, Kristin S., Neff, Frauke, Vidal, Ramon O., Hennion, Magali, Lehmann, Isabelle, Schleif, Melvin, Schröder, Susanne, Adler, Thure, Rathkolb, Birgit, Rozman, Jan, Schütz, Anna-Lena, Prehn, Cornelia, Mickael, Michel E., Weiergräber, Marco, Adamski, Jerzy, Busch, Dirk H., Ehninger, Gerhard, Matynia, Anna, Jackson, Walker S., Wolf, Eckhard, Fuchs, Helmut, Gailus-Durner, Valerie, Bonn, Stefan, Hrabě de Angelis, Martin, Ehninger, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877957/
https://www.ncbi.nlm.nih.gov/pubmed/29467291
http://dx.doi.org/10.1073/pnas.1707337115

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