Structure-based discovery of selective positive allosteric modulators of antagonists for the M(2) muscarinic acetylcholine receptor

Subtype-selective antagonists for muscarinic acetylcholine receptors (mAChRs) have long been elusive, owing to the highly conserved orthosteric binding site. However, allosteric sites of these receptors are less conserved, motivating the search for allosteric ligands that modulate agonists or antago...

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Detalles Bibliográficos
Autores principales: Korczynska, Magdalena, Clark, Mary J., Valant, Celine, Xu, Jun, Moo, Ee Von, Albold, Sabine, Weiss, Dahlia R., Torosyan, Hayarpi, Huang, Weijiao, Kruse, Andrew C., Lyda, Brent R., May, Lauren T., Baltos, Jo-Anne, Sexton, Patrick M., Kobilka, Brian K., Christopoulos, Arthur, Shoichet, Brian K., Sunahara, Roger K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877965/
https://www.ncbi.nlm.nih.gov/pubmed/29453275
http://dx.doi.org/10.1073/pnas.1718037115

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