Cargando…

Diagnostic utility of telomere length testing in a hospital-based setting

Telomere length (TL) predicts the onset of cellular senescence in vitro but the diagnostic utility of TL measurement in clinical settings is not fully known. We tested the value of TL measurement by flow cytometry and FISH (flowFISH) in patients with mutations in telomerase and telomere maintenance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alder, Jonathan K., Hanumanthu, Vidya Sagar, Strong, Margaret A., DeZern, Amy E., Stanley, Susan E., Takemoto, Clifford M., Danilova, Ludmilla, Applegate, Carolyn D., Bolton, Stephen G., Mohr, David W., Brodsky, Robert A., Casella, James F., Greider, Carol W., Jackson, J. Brooks, Armanios, Mary
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877993/ https://www.ncbi.nlm.nih.gov/pubmed/29463756 http://dx.doi.org/10.1073/pnas.1720427115

Ejemplares similares

Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction
por: Qian, Wei, et al.
Publicado: (2019)

Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations
por: Moraca, Federica, et al.
Publicado: (2017)

aPKCi triggers basal extrusion of luminal mammary epithelial cells by tuning contractility and vinculin localization at cell junctions
por: Villeneuve, Clémentine, et al.
Publicado: (2019)

Whole-chromosome paints in maize reveal rearrangements, nuclear domains, and chromosomal relationships
por: Albert, Patrice S., et al.
Publicado: (2019)

Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats
por: Fong, Louise Y., et al.
Publicado: (2018)

Distinct sets of tethering complexes, SNARE complexes, and Rab GTPases mediate membrane fusion at the vacuole in Arabidopsis
por: Takemoto, Kodai, et al.
Publicado: (2018)

Region-specific and activity-dependent regulation of SVZ neurogenesis and recovery after stroke
por: Liang, Huixuan, et al.
Publicado: (2019)

Coherent directed movement toward food modeled in Trichoplax, a ciliated animal lacking a nervous system
por: Smith, Carolyn L., et al.
Publicado: (2019)

Experimental support for alternative attractors on coral reefs
por: Schmitt, Russell J., et al.
Publicado: (2019)

Structural basis of human kinesin-8 function and inhibition
por: Locke, Julia, et al.
Publicado: (2017)

Noncanonical autophagy at ER exit sites regulates procollagen turnover
por: Omari, Shakib, et al.
Publicado: (2018)

Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension in mice
por: Lakhal-Littleton, Samira, et al.
Publicado: (2019)

Gene cluster conservation provides insight into cercosporin biosynthesis and extends production to the genus Colletotrichum
por: de Jonge, Ronnie, et al.
Publicado: (2018)

Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis
por: Nicaise, Alexandra M., et al.
Publicado: (2019)

Spontaneous driving forces give rise to protein−RNA condensates with coexisting phases and complex material properties
por: Boeynaems, Steven, et al.
Publicado: (2019)

GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency
por: Krendl, Christian, et al.
Publicado: (2017)

Pseudomonas aeruginosa transcriptome during human infection
por: Cornforth, Daniel M., et al.
Publicado: (2018)

A hypothesis linking the energy demand of the brain to obesity risk
por: Kuzawa, Christopher W., et al.
Publicado: (2019)

CFH and ARMS2 genetic risk determines progression to neovascular age-related macular degeneration after antioxidant and zinc supplementation
por: Vavvas, Demetrios G., et al.
Publicado: (2018)

Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response
por: Costantini, Todd W., et al.
Publicado: (2019)

Shift from androgen to estrogen action causes abdominal muscle fibrosis, atrophy, and inguinal hernia in a transgenic male mouse model
por: Zhao, Hong, et al.
Publicado: (2018)

Evolution of vertical and oblique transmission under fluctuating selection
por: Ram, Yoav, et al.
Publicado: (2018)

A collaborative multiyear, multimodel assessment of seasonal influenza forecasting in the United States
por: Reich, Nicholas G., et al.
Publicado: (2019)

Organizing principles for the cerebral cortex network of commissural and association connections
por: Swanson, Larry W., et al.
Publicado: (2017)

Lawful tracking of visual motion in humans, macaques, and marmosets in a naturalistic, continuous, and untrained behavioral context
por: Knöll, Jonas, et al.
Publicado: (2018)

Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy
por: Babapoor-Farrokhran, Savalan, et al.
Publicado: (2015)

Themis-associated phosphatase activity controls signaling in T cell development
por: Mehta, Monika, et al.
Publicado: (2018)

Projecting one’s own spatial bias onto others during a theory-of-mind task
por: Bio, Branden J., et al.
Publicado: (2018)

Evolution of resilience in protein interactomes across the tree of life
por: Zitnik, Marinka, et al.
Publicado: (2019)

Pairwise comparisons across species are problematic when analyzing functional genomic data
por: Dunn, Casey W., et al.
Publicado: (2018)

A major role for noncoding regulatory mutations in the evolution of enzyme activity
por: Loehlin, David W., et al.
Publicado: (2019)

Wnt/β-catenin signaling regulates ependymal cell development and adult homeostasis
por: Xing, Liujing, et al.
Publicado: (2018)

Motional dynamics of single Patched1 molecules in cilia are controlled by Hedgehog and cholesterol
por: Weiss, Lucien E., et al.
Publicado: (2019)

Nanoscale remodeling of ryanodine receptor cluster size underlies cerebral microvascular dysfunction in Duchenne muscular dystrophy
por: Pritchard, Harry A. T., et al.
Publicado: (2018)

Cell size control driven by the circadian clock and environment in cyanobacteria
por: Martins, Bruno M. C., et al.
Publicado: (2018)

Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance
por: Lim, Jonathan K. M., et al.
Publicado: (2019)

From single drug targets to synergistic network pharmacology in ischemic stroke
por: Casas, Ana I., et al.
Publicado: (2019)

Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease
por: Dunn, Amy R., et al.
Publicado: (2017)

RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases
por: Shi, Geng-Xian, et al.
Publicado: (2018)

Dendritic computations captured by an effective point neuron model
por: Li, Songting, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_i8q21p2b3gngm0in6fduul2qnf