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Defining the sizes of airborne particles that mediate influenza transmission in ferrets
Epidemics and pandemics of influenza are characterized by rapid global spread mediated by non-mutually exclusive transmission modes. The relative significance between contact, droplet, and airborne transmission is yet to be defined, a knowledge gap for implementing evidence-based infection control m...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877994/ https://www.ncbi.nlm.nih.gov/pubmed/29463703 http://dx.doi.org/10.1073/pnas.1716771115 |
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author | Zhou, Jie Wei, Jianjian Choy, Ka-Tim Sia, Sin Fun Rowlands, Dewi K. Yu, Dan Wu, Chung-Yi Lindsley, William G. Cowling, Benjamin J. McDevitt, James Peiris, Malik Li, Yuguo Yen, Hui-Ling |
author_facet | Zhou, Jie Wei, Jianjian Choy, Ka-Tim Sia, Sin Fun Rowlands, Dewi K. Yu, Dan Wu, Chung-Yi Lindsley, William G. Cowling, Benjamin J. McDevitt, James Peiris, Malik Li, Yuguo Yen, Hui-Ling |
author_sort | Zhou, Jie |
collection | PubMed |
description | Epidemics and pandemics of influenza are characterized by rapid global spread mediated by non-mutually exclusive transmission modes. The relative significance between contact, droplet, and airborne transmission is yet to be defined, a knowledge gap for implementing evidence-based infection control measures. We devised a transmission chamber that separates virus-laden particles by size and determined the particle sizes mediating transmission of influenza among ferrets through the air. Ferret-to-ferret transmission was mediated by airborne particles larger than 1.5 µm, consistent with the quantity and size of virus-laden particles released by the donors. Onward transmission by donors was most efficient before fever onset and may continue for 5 days after inoculation. Multiple virus gene segments enhanced the transmissibility of a swine influenza virus among ferrets by increasing the release of virus-laden particles into the air. We provide direct experimental evidence of influenza transmission via droplets and fine droplet nuclei, albeit at different efficiency. |
format | Online Article Text |
id | pubmed-5877994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-58779942018-04-02 Defining the sizes of airborne particles that mediate influenza transmission in ferrets Zhou, Jie Wei, Jianjian Choy, Ka-Tim Sia, Sin Fun Rowlands, Dewi K. Yu, Dan Wu, Chung-Yi Lindsley, William G. Cowling, Benjamin J. McDevitt, James Peiris, Malik Li, Yuguo Yen, Hui-Ling Proc Natl Acad Sci U S A PNAS Plus Epidemics and pandemics of influenza are characterized by rapid global spread mediated by non-mutually exclusive transmission modes. The relative significance between contact, droplet, and airborne transmission is yet to be defined, a knowledge gap for implementing evidence-based infection control measures. We devised a transmission chamber that separates virus-laden particles by size and determined the particle sizes mediating transmission of influenza among ferrets through the air. Ferret-to-ferret transmission was mediated by airborne particles larger than 1.5 µm, consistent with the quantity and size of virus-laden particles released by the donors. Onward transmission by donors was most efficient before fever onset and may continue for 5 days after inoculation. Multiple virus gene segments enhanced the transmissibility of a swine influenza virus among ferrets by increasing the release of virus-laden particles into the air. We provide direct experimental evidence of influenza transmission via droplets and fine droplet nuclei, albeit at different efficiency. National Academy of Sciences 2018-03-06 2018-02-20 /pmc/articles/PMC5877994/ /pubmed/29463703 http://dx.doi.org/10.1073/pnas.1716771115 Text en Copyright © 2018 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | PNAS Plus Zhou, Jie Wei, Jianjian Choy, Ka-Tim Sia, Sin Fun Rowlands, Dewi K. Yu, Dan Wu, Chung-Yi Lindsley, William G. Cowling, Benjamin J. McDevitt, James Peiris, Malik Li, Yuguo Yen, Hui-Ling Defining the sizes of airborne particles that mediate influenza transmission in ferrets |
title | Defining the sizes of airborne particles that mediate influenza transmission in ferrets |
title_full | Defining the sizes of airborne particles that mediate influenza transmission in ferrets |
title_fullStr | Defining the sizes of airborne particles that mediate influenza transmission in ferrets |
title_full_unstemmed | Defining the sizes of airborne particles that mediate influenza transmission in ferrets |
title_short | Defining the sizes of airborne particles that mediate influenza transmission in ferrets |
title_sort | defining the sizes of airborne particles that mediate influenza transmission in ferrets |
topic | PNAS Plus |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877994/ https://www.ncbi.nlm.nih.gov/pubmed/29463703 http://dx.doi.org/10.1073/pnas.1716771115 |
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