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Contribution of NIH funding to new drug approvals 2010–2016

This work examines the contribution of NIH funding to published research associated with 210 new molecular entities (NMEs) approved by the Food and Drug Administration from 2010–2016. We identified >2 million publications in PubMed related to the 210 NMEs (n = 131,092) or their 151 known biologic...

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Autores principales: Galkina Cleary, Ekaterina, Beierlein, Jennifer M., Khanuja, Navleen Surjit, McNamee, Laura M., Ledley, Fred D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878010/
https://www.ncbi.nlm.nih.gov/pubmed/29440428
http://dx.doi.org/10.1073/pnas.1715368115
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author Galkina Cleary, Ekaterina
Beierlein, Jennifer M.
Khanuja, Navleen Surjit
McNamee, Laura M.
Ledley, Fred D.
author_facet Galkina Cleary, Ekaterina
Beierlein, Jennifer M.
Khanuja, Navleen Surjit
McNamee, Laura M.
Ledley, Fred D.
author_sort Galkina Cleary, Ekaterina
collection PubMed
description This work examines the contribution of NIH funding to published research associated with 210 new molecular entities (NMEs) approved by the Food and Drug Administration from 2010–2016. We identified >2 million publications in PubMed related to the 210 NMEs (n = 131,092) or their 151 known biological targets (n = 1,966,281). Of these, >600,000 (29%) were associated with NIH-funded projects in RePORTER. This funding included >200,000 fiscal years of NIH project support (1985–2016) and project costs >$100 billion (2000–2016), representing ∼20% of the NIH budget over this period. NIH funding contributed to every one of the NMEs approved from 2010–2016 and was focused primarily on the drug targets rather than on the NMEs themselves. There were 84 first-in-class products approved in this interval, associated with >$64 billion of NIH-funded projects. The percentage of fiscal years of project funding identified through target searches, but not drug searches, was greater for NMEs discovered through targeted screening than through phenotypic methods (95% versus 82%). For targeted NMEs, funding related to targets preceded funding related to the NMEs, consistent with the expectation that basic research provides validated targets for targeted screening. This analysis, which captures basic research on biological targets as well as applied research on NMEs, suggests that the NIH contribution to research associated with new drug approvals is greater than previously appreciated and highlights the risk of reducing federal funding for basic biomedical research.
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spelling pubmed-58780102018-04-02 Contribution of NIH funding to new drug approvals 2010–2016 Galkina Cleary, Ekaterina Beierlein, Jennifer M. Khanuja, Navleen Surjit McNamee, Laura M. Ledley, Fred D. Proc Natl Acad Sci U S A Social Sciences This work examines the contribution of NIH funding to published research associated with 210 new molecular entities (NMEs) approved by the Food and Drug Administration from 2010–2016. We identified >2 million publications in PubMed related to the 210 NMEs (n = 131,092) or their 151 known biological targets (n = 1,966,281). Of these, >600,000 (29%) were associated with NIH-funded projects in RePORTER. This funding included >200,000 fiscal years of NIH project support (1985–2016) and project costs >$100 billion (2000–2016), representing ∼20% of the NIH budget over this period. NIH funding contributed to every one of the NMEs approved from 2010–2016 and was focused primarily on the drug targets rather than on the NMEs themselves. There were 84 first-in-class products approved in this interval, associated with >$64 billion of NIH-funded projects. The percentage of fiscal years of project funding identified through target searches, but not drug searches, was greater for NMEs discovered through targeted screening than through phenotypic methods (95% versus 82%). For targeted NMEs, funding related to targets preceded funding related to the NMEs, consistent with the expectation that basic research provides validated targets for targeted screening. This analysis, which captures basic research on biological targets as well as applied research on NMEs, suggests that the NIH contribution to research associated with new drug approvals is greater than previously appreciated and highlights the risk of reducing federal funding for basic biomedical research. National Academy of Sciences 2018-03-06 2018-02-12 /pmc/articles/PMC5878010/ /pubmed/29440428 http://dx.doi.org/10.1073/pnas.1715368115 Text en Copyright © 2018 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Social Sciences
Galkina Cleary, Ekaterina
Beierlein, Jennifer M.
Khanuja, Navleen Surjit
McNamee, Laura M.
Ledley, Fred D.
Contribution of NIH funding to new drug approvals 2010–2016
title Contribution of NIH funding to new drug approvals 2010–2016
title_full Contribution of NIH funding to new drug approvals 2010–2016
title_fullStr Contribution of NIH funding to new drug approvals 2010–2016
title_full_unstemmed Contribution of NIH funding to new drug approvals 2010–2016
title_short Contribution of NIH funding to new drug approvals 2010–2016
title_sort contribution of nih funding to new drug approvals 2010–2016
topic Social Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878010/
https://www.ncbi.nlm.nih.gov/pubmed/29440428
http://dx.doi.org/10.1073/pnas.1715368115
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