Vascular deficiency of Smad4 causes arteriovenous malformations: a mouse model of Hereditary Hemorrhagic Telangiectasia

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder that leads to abnormal connections between arteries and veins termed arteriovenous malformations (AVM). Mutations in TGFβ pathway members ALK1, ENG and SMAD4 lead to HHT. However, a Smad4 mouse model of HHT does n...

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Detalles Bibliográficos
Autores principales: Crist, Angela M., Lee, Amanda R., Patel, Nehal R., Westhoff, Dawn E., Meadows, Stryder M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878194/
https://www.ncbi.nlm.nih.gov/pubmed/29460088
http://dx.doi.org/10.1007/s10456-018-9602-0

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