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Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico
Blastocystis subtype 3 (ST3) is a parasitic protist found in the digestive tract of symptomatic and asymptomatic humans around the world. While this parasite exhibits a high prevalence in the human population, its true geographic distribution and global genetic diversity are still unknown. This gap...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878905/ https://www.ncbi.nlm.nih.gov/pubmed/29744356 http://dx.doi.org/10.1155/2018/3916263 |
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author | Rojas-Velázquez, Liliana Morán, Patricia Serrano-Vázquez, Angélica Fernández, Leonardo D. Pérez-Juárez, Horacio Poot-Hernández, Augusto C. Portillo, Tobías González, Enrique Hernández, Eric Partida-Rodríguez, Oswaldo Nieves-Ramírez, Miriam E. Magaña, Ulises Torres, Javier Eguiarte, Luis E. Piñero, Daniel Ximénez, Cecilia |
author_facet | Rojas-Velázquez, Liliana Morán, Patricia Serrano-Vázquez, Angélica Fernández, Leonardo D. Pérez-Juárez, Horacio Poot-Hernández, Augusto C. Portillo, Tobías González, Enrique Hernández, Eric Partida-Rodríguez, Oswaldo Nieves-Ramírez, Miriam E. Magaña, Ulises Torres, Javier Eguiarte, Luis E. Piñero, Daniel Ximénez, Cecilia |
author_sort | Rojas-Velázquez, Liliana |
collection | PubMed |
description | Blastocystis subtype 3 (ST3) is a parasitic protist found in the digestive tract of symptomatic and asymptomatic humans around the world. While this parasite exhibits a high prevalence in the human population, its true geographic distribution and global genetic diversity are still unknown. This gap in knowledge limits the understanding of the spread mechanisms, epidemiology, and impact that this parasite has on human populations. Herein, we provided new data on the geographical distribution and genetic diversity of Blastocystis ST3 from a rural human population in Mexico. To do so, we collected and targeted the SSU-rDNA region in fecal samples from this population and further compared its genetic diversity and structure with that previously observed in populations of Blastocystis ST3 from other regions of the planet. Our analyses reveled that diversity of Blastocystis ST3 showed a high haplotype diversity and genetic structure to the world level; however, they were low in the Morelos population. The haplotype network revealed a common widespread haplotype from which the others were generated recently. Finally, our results suggested a recent expansion of the diversity of Blastocystis ST3 worldwide. |
format | Online Article Text |
id | pubmed-5878905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58789052018-05-09 Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico Rojas-Velázquez, Liliana Morán, Patricia Serrano-Vázquez, Angélica Fernández, Leonardo D. Pérez-Juárez, Horacio Poot-Hernández, Augusto C. Portillo, Tobías González, Enrique Hernández, Eric Partida-Rodríguez, Oswaldo Nieves-Ramírez, Miriam E. Magaña, Ulises Torres, Javier Eguiarte, Luis E. Piñero, Daniel Ximénez, Cecilia Biomed Res Int Research Article Blastocystis subtype 3 (ST3) is a parasitic protist found in the digestive tract of symptomatic and asymptomatic humans around the world. While this parasite exhibits a high prevalence in the human population, its true geographic distribution and global genetic diversity are still unknown. This gap in knowledge limits the understanding of the spread mechanisms, epidemiology, and impact that this parasite has on human populations. Herein, we provided new data on the geographical distribution and genetic diversity of Blastocystis ST3 from a rural human population in Mexico. To do so, we collected and targeted the SSU-rDNA region in fecal samples from this population and further compared its genetic diversity and structure with that previously observed in populations of Blastocystis ST3 from other regions of the planet. Our analyses reveled that diversity of Blastocystis ST3 showed a high haplotype diversity and genetic structure to the world level; however, they were low in the Morelos population. The haplotype network revealed a common widespread haplotype from which the others were generated recently. Finally, our results suggested a recent expansion of the diversity of Blastocystis ST3 worldwide. Hindawi 2018-03-18 /pmc/articles/PMC5878905/ /pubmed/29744356 http://dx.doi.org/10.1155/2018/3916263 Text en Copyright © 2018 Liliana Rojas-Velázquez et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Rojas-Velázquez, Liliana Morán, Patricia Serrano-Vázquez, Angélica Fernández, Leonardo D. Pérez-Juárez, Horacio Poot-Hernández, Augusto C. Portillo, Tobías González, Enrique Hernández, Eric Partida-Rodríguez, Oswaldo Nieves-Ramírez, Miriam E. Magaña, Ulises Torres, Javier Eguiarte, Luis E. Piñero, Daniel Ximénez, Cecilia Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico |
title | Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico |
title_full | Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico |
title_fullStr | Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico |
title_full_unstemmed | Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico |
title_short | Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico |
title_sort | genetic diversity and distribution of blastocystis subtype 3 in human populations, with special reference to a rural population in central mexico |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878905/ https://www.ncbi.nlm.nih.gov/pubmed/29744356 http://dx.doi.org/10.1155/2018/3916263 |
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