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Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico

Blastocystis subtype 3 (ST3) is a parasitic protist found in the digestive tract of symptomatic and asymptomatic humans around the world. While this parasite exhibits a high prevalence in the human population, its true geographic distribution and global genetic diversity are still unknown. This gap...

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Autores principales: Rojas-Velázquez, Liliana, Morán, Patricia, Serrano-Vázquez, Angélica, Fernández, Leonardo D., Pérez-Juárez, Horacio, Poot-Hernández, Augusto C., Portillo, Tobías, González, Enrique, Hernández, Eric, Partida-Rodríguez, Oswaldo, Nieves-Ramírez, Miriam E., Magaña, Ulises, Torres, Javier, Eguiarte, Luis E., Piñero, Daniel, Ximénez, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878905/
https://www.ncbi.nlm.nih.gov/pubmed/29744356
http://dx.doi.org/10.1155/2018/3916263
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author Rojas-Velázquez, Liliana
Morán, Patricia
Serrano-Vázquez, Angélica
Fernández, Leonardo D.
Pérez-Juárez, Horacio
Poot-Hernández, Augusto C.
Portillo, Tobías
González, Enrique
Hernández, Eric
Partida-Rodríguez, Oswaldo
Nieves-Ramírez, Miriam E.
Magaña, Ulises
Torres, Javier
Eguiarte, Luis E.
Piñero, Daniel
Ximénez, Cecilia
author_facet Rojas-Velázquez, Liliana
Morán, Patricia
Serrano-Vázquez, Angélica
Fernández, Leonardo D.
Pérez-Juárez, Horacio
Poot-Hernández, Augusto C.
Portillo, Tobías
González, Enrique
Hernández, Eric
Partida-Rodríguez, Oswaldo
Nieves-Ramírez, Miriam E.
Magaña, Ulises
Torres, Javier
Eguiarte, Luis E.
Piñero, Daniel
Ximénez, Cecilia
author_sort Rojas-Velázquez, Liliana
collection PubMed
description Blastocystis subtype 3 (ST3) is a parasitic protist found in the digestive tract of symptomatic and asymptomatic humans around the world. While this parasite exhibits a high prevalence in the human population, its true geographic distribution and global genetic diversity are still unknown. This gap in knowledge limits the understanding of the spread mechanisms, epidemiology, and impact that this parasite has on human populations. Herein, we provided new data on the geographical distribution and genetic diversity of Blastocystis ST3 from a rural human population in Mexico. To do so, we collected and targeted the SSU-rDNA region in fecal samples from this population and further compared its genetic diversity and structure with that previously observed in populations of Blastocystis ST3 from other regions of the planet. Our analyses reveled that diversity of Blastocystis ST3 showed a high haplotype diversity and genetic structure to the world level; however, they were low in the Morelos population. The haplotype network revealed a common widespread haplotype from which the others were generated recently. Finally, our results suggested a recent expansion of the diversity of Blastocystis ST3 worldwide.
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spelling pubmed-58789052018-05-09 Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico Rojas-Velázquez, Liliana Morán, Patricia Serrano-Vázquez, Angélica Fernández, Leonardo D. Pérez-Juárez, Horacio Poot-Hernández, Augusto C. Portillo, Tobías González, Enrique Hernández, Eric Partida-Rodríguez, Oswaldo Nieves-Ramírez, Miriam E. Magaña, Ulises Torres, Javier Eguiarte, Luis E. Piñero, Daniel Ximénez, Cecilia Biomed Res Int Research Article Blastocystis subtype 3 (ST3) is a parasitic protist found in the digestive tract of symptomatic and asymptomatic humans around the world. While this parasite exhibits a high prevalence in the human population, its true geographic distribution and global genetic diversity are still unknown. This gap in knowledge limits the understanding of the spread mechanisms, epidemiology, and impact that this parasite has on human populations. Herein, we provided new data on the geographical distribution and genetic diversity of Blastocystis ST3 from a rural human population in Mexico. To do so, we collected and targeted the SSU-rDNA region in fecal samples from this population and further compared its genetic diversity and structure with that previously observed in populations of Blastocystis ST3 from other regions of the planet. Our analyses reveled that diversity of Blastocystis ST3 showed a high haplotype diversity and genetic structure to the world level; however, they were low in the Morelos population. The haplotype network revealed a common widespread haplotype from which the others were generated recently. Finally, our results suggested a recent expansion of the diversity of Blastocystis ST3 worldwide. Hindawi 2018-03-18 /pmc/articles/PMC5878905/ /pubmed/29744356 http://dx.doi.org/10.1155/2018/3916263 Text en Copyright © 2018 Liliana Rojas-Velázquez et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rojas-Velázquez, Liliana
Morán, Patricia
Serrano-Vázquez, Angélica
Fernández, Leonardo D.
Pérez-Juárez, Horacio
Poot-Hernández, Augusto C.
Portillo, Tobías
González, Enrique
Hernández, Eric
Partida-Rodríguez, Oswaldo
Nieves-Ramírez, Miriam E.
Magaña, Ulises
Torres, Javier
Eguiarte, Luis E.
Piñero, Daniel
Ximénez, Cecilia
Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico
title Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico
title_full Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico
title_fullStr Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico
title_full_unstemmed Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico
title_short Genetic Diversity and Distribution of Blastocystis Subtype 3 in Human Populations, with Special Reference to a Rural Population in Central Mexico
title_sort genetic diversity and distribution of blastocystis subtype 3 in human populations, with special reference to a rural population in central mexico
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878905/
https://www.ncbi.nlm.nih.gov/pubmed/29744356
http://dx.doi.org/10.1155/2018/3916263
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