MAGE‐A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer

BACKGROUND: MAGE‐A genes belong to the cancer/testis antigens family. The prognostic significance of MAGE‐A expression in the peripheral blood of patients with lung cancer is unknown. Therefore, this study evaluated the expression and possible prognostic significance of MAGE‐A in the peripheral bloo...

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Detalles Bibliográficos
Autores principales: Gu, Lina, Sang, Meixiang, Yin, Danjing, Liu, Fei, Wu, Yunyan, Liu, Shina, Huang, Weina, Shan, Baoen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879056/
https://www.ncbi.nlm.nih.gov/pubmed/29430849
http://dx.doi.org/10.1111/1759-7714.12571
Descripción
Sumario:BACKGROUND: MAGE‐A genes belong to the cancer/testis antigens family. The prognostic significance of MAGE‐A expression in the peripheral blood of patients with lung cancer is unknown. Therefore, this study evaluated the expression and possible prognostic significance of MAGE‐A in the peripheral blood of patients with lung cancer. METHODS: In this study, we detected MAGE‐A gene expression in the peripheral blood of 150 patients with lung cancer and 30 healthy donors using multiplex semi‐nested PCR and analyzed their correlation with clinicopathological risk factors. RESULTS: MAGE‐A expression was associated with factors indicating poor prognosis. The expression of MAGE‐A and each individual MAGE‐A gene were also associated with low overall survival in patients with lung cancer. CONCLUSION: The expression of MAGE‐A genes in peripheral blood may act as a poor prognostic marker in patients with lung cancer.

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