MAGE‐A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer

BACKGROUND: MAGE‐A genes belong to the cancer/testis antigens family. The prognostic significance of MAGE‐A expression in the peripheral blood of patients with lung cancer is unknown. Therefore, this study evaluated the expression and possible prognostic significance of MAGE‐A in the peripheral bloo...

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Detalles Bibliográficos
Autores principales: Gu, Lina, Sang, Meixiang, Yin, Danjing, Liu, Fei, Wu, Yunyan, Liu, Shina, Huang, Weina, Shan, Baoen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879056/
https://www.ncbi.nlm.nih.gov/pubmed/29430849
http://dx.doi.org/10.1111/1759-7714.12571
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author Gu, Lina
Sang, Meixiang
Yin, Danjing
Liu, Fei
Wu, Yunyan
Liu, Shina
Huang, Weina
Shan, Baoen
author_facet Gu, Lina
Sang, Meixiang
Yin, Danjing
Liu, Fei
Wu, Yunyan
Liu, Shina
Huang, Weina
Shan, Baoen
author_sort Gu, Lina
collection PubMed
description BACKGROUND: MAGE‐A genes belong to the cancer/testis antigens family. The prognostic significance of MAGE‐A expression in the peripheral blood of patients with lung cancer is unknown. Therefore, this study evaluated the expression and possible prognostic significance of MAGE‐A in the peripheral blood of patients with lung cancer. METHODS: In this study, we detected MAGE‐A gene expression in the peripheral blood of 150 patients with lung cancer and 30 healthy donors using multiplex semi‐nested PCR and analyzed their correlation with clinicopathological risk factors. RESULTS: MAGE‐A expression was associated with factors indicating poor prognosis. The expression of MAGE‐A and each individual MAGE‐A gene were also associated with low overall survival in patients with lung cancer. CONCLUSION: The expression of MAGE‐A genes in peripheral blood may act as a poor prognostic marker in patients with lung cancer.
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spelling pubmed-58790562018-04-04 MAGE‐A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer Gu, Lina Sang, Meixiang Yin, Danjing Liu, Fei Wu, Yunyan Liu, Shina Huang, Weina Shan, Baoen Thorac Cancer Original Articles BACKGROUND: MAGE‐A genes belong to the cancer/testis antigens family. The prognostic significance of MAGE‐A expression in the peripheral blood of patients with lung cancer is unknown. Therefore, this study evaluated the expression and possible prognostic significance of MAGE‐A in the peripheral blood of patients with lung cancer. METHODS: In this study, we detected MAGE‐A gene expression in the peripheral blood of 150 patients with lung cancer and 30 healthy donors using multiplex semi‐nested PCR and analyzed their correlation with clinicopathological risk factors. RESULTS: MAGE‐A expression was associated with factors indicating poor prognosis. The expression of MAGE‐A and each individual MAGE‐A gene were also associated with low overall survival in patients with lung cancer. CONCLUSION: The expression of MAGE‐A genes in peripheral blood may act as a poor prognostic marker in patients with lung cancer. John Wiley & Sons Australia, Ltd 2018-02-12 2018-04 /pmc/articles/PMC5879056/ /pubmed/29430849 http://dx.doi.org/10.1111/1759-7714.12571 Text en © 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Gu, Lina
Sang, Meixiang
Yin, Danjing
Liu, Fei
Wu, Yunyan
Liu, Shina
Huang, Weina
Shan, Baoen
MAGE‐A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer
title MAGE‐A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer
title_full MAGE‐A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer
title_fullStr MAGE‐A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer
title_full_unstemmed MAGE‐A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer
title_short MAGE‐A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer
title_sort mage‐a gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879056/
https://www.ncbi.nlm.nih.gov/pubmed/29430849
http://dx.doi.org/10.1111/1759-7714.12571
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